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Lack of association between microRNA-137 SNP rs1625579 and schizophrenia in a replication study of Han Chinese

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Abstract

Schizophrenia (SCZ) is a common, complex and severe psychiatric disorder associated with many different genetic and environmental risk factors. A recent genome-wide association study identified a single-nucleotide polymorphism (SNP, rs1625579) in microRNA-137 (miR-137) as a possible susceptibility locus for SCZ. Hoping to validate this finding, we conducted a case–control study of the Han Chinese population, with 506 SCZ cases and 522 healthy controls, using the Ligase detection reaction–polymerase chain reaction method to genotype the polymorphism rs1625579 in the miR-137 gene. However, we found no significant difference (P > 0.05) in either allele or genotype frequency in this SNP between patients and controls. In addition, a meta-analysis indicated that the ‘T’ allele of SNP rs1625579 was not associated with susceptibility to SCZ in Han Chinese populations (pooled OR 1.087, 95 % CI 0.847–1.396, P = 0.512). Thus, these results do not support the previous finding suggesting further replication studies using a large-scale association analysis that should be warranted in Han Chinese populations.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (No.81301147) and the Science & Technology Development Foundation of Wuxi Municipal Science & Technology Bureau (CSZON1316).

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The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Wuxi Mental Health Center Affiliated to Nanjing Medical University, Wuxi, 214151, Jiangsu Province, China

    Jianmin Yuan, Zaohuo Cheng, Fuquan Zhang, Zhenhe Zhou, Shui Yu & Chunhui Jin

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  1. Jianmin Yuan
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  2. Zaohuo Cheng
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  3. Fuquan Zhang
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  4. Zhenhe Zhou
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  5. Shui Yu
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  6. Chunhui Jin
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Correspondence to Chunhui Jin.

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Communicated by S. Hohmann.

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Yuan, J., Cheng, Z., Zhang, F. et al. Lack of association between microRNA-137 SNP rs1625579 and schizophrenia in a replication study of Han Chinese. Mol Genet Genomics 290, 297–301 (2015). https://doi.org/10.1007/s00438-014-0924-3

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  • DOI: https://doi.org/10.1007/s00438-014-0924-3

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