Abstract
In the previous work, methanol extracts of Carpesium rosulatum (Compositae) were found to have high antiplasmodial activity against Plasmodium falciparum in vitro, this activity being largely attributable to a ineupatorolides A (I-A). In the present study, encouragingly, I-A was also found to have potential antimalarial activity in vivo when tested against Plasmodium berghei in mice. I-A (2, 5, 10 mg kg−1 day−1) exhibited a significant blood schizontocidal activity in 4-day early infection, repository evaluation, and in established infection with a significant mean survival time comparable to that of the standard drug, chloroquine (5 mg kg−1 day−1). The I-A possesses a promising antiplasmodial activity, which can be exploited in malaria therapy.
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Chung, IM., Kim, MY. & Moon, HI. Antiplasmodial activity of sesquiterpene lactone from Carpesium rosulatum in mice. Parasitol Res 103, 341–344 (2008). https://doi.org/10.1007/s00436-008-0977-5
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DOI: https://doi.org/10.1007/s00436-008-0977-5