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Elevated risk of colorectal cancer associated with the AA genotype of the cyclin D1 A870G polymorphism in an Indian population

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Abstract

Purpose: To investigate whether the common cyclin D1 (CCND1) A870G polymorphism is a risk factor for colorectal cancer (CRC) in an Indian population. Methods: In this study, 301 newly diagnosed CRC patients and 291 healthy control subjects were genotyped by the PCR-RFLP method. Genotype frequencies were compared between cases and controls, and the association of genotypes with CRC was studied. Results: The CCND1 870 A allele was more frequently observed in CRC patients than controls (0.63 vs. 0.56, P=0.01), and after adjustment for age, sex, smoking habits, family history, family income and the consumption of meat, fish, vegetables and fruit, an increased risk was observed for the AA genotype compared to the GG+AG genotype (OR=1.56; 95% CI: 1.10–2.21). The increased risk were also found for colon (OR=1.96; 95% CI: 1.08–3.57) and rectal cancer (OR=1.51; 95% CI: 1.04–2.19). No correlation was observed between genotypes and age of diagnosis of CRC (49.9, 48.7 and 49.4 years for the GG, AG and AA genotypes, respectively; P=0.84). Multivariate analysis also revealed a stronger positive association with the AA genotype among patients with high meat intake (OR=2.67; 95% CI: 1.29–5.51), and particularly significant inverse associations with the GG+AG genotypes were also found for those with high vegetable consumption (OR=0.46; 95% CI: 0.27–0.79 of 2–3 servings/day, and OR=0.31; 95% CI: 0.18–0.53 for >3 servings/day) and fish intake (OR=0.48; 95% CI: 0.28–0.82). Conclusion: These data support the hypothesis that the CCND1 A870G polymorphism may increase the risk of CRC in our Indian population.

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Acknowledgements

This work was supported in part by the International Scientific Research Program, Special Cancer Research of the Japanese Ministry of Education, Culture, Sports, Science and Technology. We thank Drs. V. Shanta and. T. Rajkumar at the Cancer Institute, Chennai, India for their cooperation.

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Authors and Affiliations

  1. Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences, 467-8601, Nagoya, Japan

    Jing Jiang, Jingweng Wang, Sadao Suzuki, Kiyonori Kuriki, Yang Zhao & Shinkan Tokudome

  2. Epidemiological Research Center, Chennai, India

    Vendhan Gajalakshmi

  3. Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan

    Kiyonori Kuriki

  4. Health Research Foundation, Kyoto, Japan

    Seiichi Nakamura

  5. Department of Occupational Health, Osaka Prefectural Institute of Public Health, Osaka, Japan

    Susumu Akasaka

  6. Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Hideki Ishikawa

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  1. Jing Jiang
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  2. Jingweng Wang
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Correspondence to Shinkan Tokudome.

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Jiang, J., Wang, J., Suzuki, S. et al. Elevated risk of colorectal cancer associated with the AA genotype of the cyclin D1 A870G polymorphism in an Indian population. J Cancer Res Clin Oncol 132, 193–199 (2006). https://doi.org/10.1007/s00432-005-0039-7

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  • DOI: https://doi.org/10.1007/s00432-005-0039-7

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