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p34cdc2 expression is an independent indicator for lymph node metastasis in colorectal carcinoma

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Abstract

Purpose

The significance of p34cdc2 expression in human tumors has not been fully explained. The aim of the current study was to elucidate the clinicopathologic significance of immunohistochemical p34cdc2 expression in carcinoma of the colon and rectum.

Methods

The immunohistochemical expression of p34cdc2 was examined in 90 consecutive colorectal tumor cases, and p34cdc2 expression and the clinicopathologic features of the patients and their tumors were compared.

Results

Lymph node metastasis was significantly more frequent in tumors expressing p34cdc2 (47.8%, 11 of 23 tumors) than in tumors not expressing p34cdc2 (22.4%, 15 of 67 tumors; P=0.020). Multivariate analysis demonstrated that tumor depth (P=0.008) and p34cdc2 expression (P=0.022) were independently associated with lymph node metastases of colorectal carcinomas.

Conclusions

The immunohistochemical expression of p34cdc2 is independently associated with lymph node metastasis in colorectal carcinoma.

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Acknowledgements

This study was supported by a grant-in-aid from the Ministry of Education, Science, Sports and Culture of Japan (Frontier Research Grant).

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Authors and Affiliations

  1. Department of General Surgery, Fukuoka Dental College Hospital, Sawara Ward, 2-15-1 Tamura, 814-0193, Fukuoka, Japan

    T. Nozoe, M. Honda, S. Inutsuka & D. Korenaga

Authors
  1. T. Nozoe
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  2. M. Honda
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  3. S. Inutsuka
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  4. D. Korenaga
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Correspondence to T. Nozoe.

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Nozoe, T., Honda, M., Inutsuka, S. et al. p34cdc2 expression is an independent indicator for lymph node metastasis in colorectal carcinoma. J Cancer Res Clin Oncol 129, 498–502 (2003). https://doi.org/10.1007/s00432-003-0474-2

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  • DOI: https://doi.org/10.1007/s00432-003-0474-2

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