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Trend of eGFR in an Italian cohort of mother-to-child HIV-infected patients exposed to tenofovir for at least 2 years

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Abstract

The aim of this study is to describe longitudinal changes in estimated glomerular filtration rate (eGFR) in a cohort of mother-to-child HIV-infected adolescents exposed to tenofovir dixoproxil fumarate (TDF) for at least 2 years. We retrospectively examined eGFR at starting TDF (T0), at 24 months (T2) and at the final assessment (T3). Twenty-nine patients were studied. The mean duration of TDF exposure was 67 months (24–123). At baseline, the mean eGFR was 152 ml/min/1.73 m2 (105–227, SD, 33). There was a significant decrease of eGFR from a mean of 152 ml/min/1.73 m2 (SD, 33) at T0 to 140 ml/min/1.73 m2 (SD, 33) at T2 and 123 ml/min/1.73 m2 (SD, 14) at T3. The decrease of eGFR was significant, with ΔGFR (T3-T0) of −29 ml/min/1.73 m2 (SD, 30; p < 0.0001) and a mean ΔGFR per year of −6 and ml/min/1.73 m2 (SD, 8).

Conclusion: We noted a long-term decline in eGFR in this small cohort of mother-to-child HIV-infected adolescents receiving TDF-containing cART, even if the lack of a control group and the small sample size are major limitations.

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Fig. 1

Abbreviations

cART:

Combined antiretroviral therapy

eGFR:

Estimated glomerular filtration rate

HBV:

Hepatitis B virus

HCV:

Hepatitis C virus

PI:

Protease inhibitor

TDF:

Tenofovir dixoproxil fumarate

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Aknowledgments

Dr. Raffaella Rosso passed away during the development of this manuscript. She first had the idea to start this work and collect data.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Infectious Diseases Unit, IRCCS San Martino University Hospital-IST, University of Genoa, L.go Rosanna Benzi 10, 16132, Genoa, Italy

    Sara Grignolo, Paola Tatarelli, Giulia Gustinetti, Claudio Viscoli & Antonio Di Biagio

  2. Department of Nephrology, IRCCS San Martino University Hospital-IST, University of Genoa, L.go Rosanna Benzi 10, 16132, Genoa, Italy

    Francesca Viazzi & Barbara Bonino

  3. Infectious Diseases Unit, General Hospital University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy

    Paolo Maggi

Authors
  1. Sara Grignolo
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  2. Paola Tatarelli
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  3. Giulia Gustinetti
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  4. Francesca Viazzi
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  5. Barbara Bonino
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  6. Paolo Maggi
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  7. Claudio Viscoli
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  8. Antonio Di Biagio
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Corresponding author

Correspondence to Paola Tatarelli.

Additional information

Communicated by David Nadal

Revisions received: 10 October 2014/17 November 2014/25 November 2014

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Grignolo, S., Tatarelli, P., Gustinetti, G. et al. Trend of eGFR in an Italian cohort of mother-to-child HIV-infected patients exposed to tenofovir for at least 2 years. Eur J Pediatr 174, 843–846 (2015). https://doi.org/10.1007/s00431-014-2468-2

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  • DOI: https://doi.org/10.1007/s00431-014-2468-2

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