Abstract
A breast tumor in a 52-year-old female was interpreted as a malignant myoepithelioma based on morphological and immunohistochemical studies. The tumor consisted of elongated cells with clear cytoplasm and lacked glandular components. The tumor cells were stained positively for keratin, S-100 protein, glial fibrillary acidic protein (GFAP) and muscle-specific actin. Distant metastasis in the right jaw developed 8 years after the initial surgery and the metastatic deposit showed a similar morphology and immunoreactivity. Myoepithelial tumors are generally considered as benign or low-grade lesions and distant metastasis has been rarely documented. The present case presents the possibility of delayed occurrence of distant metastasis in myoepithelial tumor of the breast.
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Received: 22 January 1999 / Accepted: 18 May 1999
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Shiraishi, T., Nakayama, T., Fukutome, K. et al. Malignant myoepithelioma of the breast metastasizing to the jaw. Virchows Archiv 435, 520–523 (1999). https://doi.org/10.1007/s004280050436
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DOI: https://doi.org/10.1007/s004280050436