Abstract
This review provides an overview of the molecular mechanisms of K transport in the mammalian connecting tubule (CNT) and cortical collecting duct (CCD), both nephron segments responsible for the regulation of renal K secretion. Aldosterone and dietary K intake are two of the most important factors regulating K secretion in the CNT and CCD. Recently, angiotensin II (AngII) has also been shown to play a role in the regulation of K secretion. In addition, genetic and molecular biological approaches have further identified new mechanisms by which aldosterone and dietary K intake regulate K transport. Thus, the interaction between serum-glucocorticoid-induced kinase 1 (SGK1) and with-no-lysine kinase 4 (WNK4) plays a significant role in mediating the effect of aldosterone on ROMK (Kir1.1), an important apical K channel modulating K secretion. Recent evidence suggests that WNK1, mitogen-activated protein kinases such as P38, ERK, and Src family protein tyrosine kinase are involved in mediating the effect of low K intake on apical K secretory channels.
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Acknowledgment
We dedicate this manuscript to Dr. Steven H. Hebert, our friend and colleague who died quite unexpectedly on April 15th 2008. We lost with him a long-standing collaborator, friend, and an investigator who made major contributions in the field of potassium transport. The authors also thank Drs. D. Mount and R. B. Silver for their insightful comments. The work is supported by NIH grants DK 47402, DK54983 and HL34100.
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Wang, WH., Giebisch, G. Regulation of potassium (K) handling in the renal collecting duct. Pflugers Arch - Eur J Physiol 458, 157–168 (2009). https://doi.org/10.1007/s00424-008-0593-3
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DOI: https://doi.org/10.1007/s00424-008-0593-3