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Electrical stimulation for testing neuromuscular function: from sport to pathology

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Abstract

The use of electrical stimulation (ES) can contribute to our knowledge of how our neuromuscular system can adapt to physical stress or unloading. Although it has been recently challenged, the standard technique used to explore central modifications is the twitch interpolated method which consists in superimposing single twitches or high-frequency doublets on a maximal voluntary contraction (MVC) and to compare the superimposed response to the potentiated response obtained from the relaxed muscle. Alternative methods consist in (1) superimposing a train of stimuli (central activation ratio), (2) comparing the MVC response to the force evoked by a high-frequency tetanus or (3) examining the change in maximal EMG response during voluntary contractions, if this variable is normalized to the maximal M wave, i.e. EMG response to a single stimulus. ES is less used to examine supraspinal factors but it is useful for investigating changes at the spinal level, either by using H reflexes, F waves or cervicomedullary motor-evoked potentials. Peripheral changes can be examined with ES, usually by stimulating the muscle in the relaxed state. Neuromuscular propagation of action potentials on the sarcolemma (M wave, high-frequency fatigue), excitation–contraction coupling (e.g. low-frequency fatigue) and intrinsic force (high-frequency stimulation at supramaximal intensity) can all be used to non-invasively explore muscular function with ES. As for all indirect methods, there are limitations and these are discussed in this review. Finally, (1) ES as a method to measure respiratory muscle function and (2) the comparison between electrical and magnetic stimulation will also be considered.

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Authors and Affiliations

  1. Université de Lyon, 42023, Saint-Etienne, France

    Guillaume Y. Millet

  2. Inserm U1042, Grenoble, 38000, France

    Guillaume Y. Millet & Samuel Vergès

  3. Exercise Physiology Laboratory, Bâtiment Médecine du Sport, Myologie, Hôpital Bellevue, 42055, Saint-Etienne Cedex 2, France

    Guillaume Y. Millet

  4. Clermont Université, Blaise Pascal University, EA 3533, Laboratory of Biology of Physical Activity, Clermont-Ferrand, France

    Vincent Martin

  5. INSERM U887 Laboratory, University of Burgundy, Dijon, France

    Alain Martin

  6. HP2 Laboratory, Joseph Fourier University and Exercise Research Unit, University Hospital, Grenoble, France

    Samuel Vergès

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  1. Guillaume Y. Millet
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  2. Vincent Martin
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Correspondence to Guillaume Y. Millet.

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Communicated by Roberto Bottinelli.

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Millet, G.Y., Martin, V., Martin, A. et al. Electrical stimulation for testing neuromuscular function: from sport to pathology. Eur J Appl Physiol 111, 2489–2500 (2011). https://doi.org/10.1007/s00421-011-1996-y

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