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Multipurpose ultrasonographic characteristics of primary uveal MALT lymphoma

  • Oncology
  • Published:
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Abstract

Purpose

To investigate the ultrasonographic features in patients with primary uveal mucosa-associated lymphoid tissue (MALT) lymphoma.

Methods

Medical records of 12 patients (13 eyes) diagnosed with primary uveal MALT lymphoma between September 2014 and September 2021 were retrospectively reviewed. Ultrasonography, B-scan ultrasonography, color Doppler flow imaging, and ultrasound biomicroscopy findings were retrieved from the medical records.

Results

Mean age of the included patients was 59.4 ± 8.6 years. Typical ultrasonographic features of the choroidal infiltrates were flat, diffuse, and thickened, with low and homogenous internal reflectivity and with rich arterial blood flow from posterior ciliary arterioles. The mean thickness of the choroidal infiltrates was 1.34 ± 0.68 mm (n = 13). Most of the affected eyes had posterior episcleral extensions, with a mean thickness of 1.66 ± 1.21 mm (n = 12). Typical crescent-like posterior episcleral extensions were detected in nine eyes (69.2%). In six eyes, the blood flow from the choroidal infiltrates communicated with the episcleral extensions. In the ciliary body, the mean thickness of the infiltrates was 1.08 ± 0.43 mm (n = 9), and seven eyes (77.8%) had 360° ring-like infiltrations. The initial best-corrected visual acuity (BCVA) was significantly correlated with the final BCVA after treatment (p < 0.001).

Conclusion

Multipurpose ultrasonographic imaging revealed the unique characteristics of the primary uveal MALT lymphoma and is helpful in the diagnosis of this rare disease.

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Funding

This work was supported by the Clinical Research Plan of SHDC (SHDC2020CR2041B).

Author information

Author notes

  1. Lili Zhang and Ting Zhang contributed equally to this work.

Authors and Affiliations

  1. Department of Ophthalmology, Eye, Ear, Nose and Throat Hospital, Shanghai Medical School, Fudan University, Shanghai, 200031, China

    Lili Zhang, Ting Zhang, Gezhi Xu, Chaoran Zhang, Jiang Qian, Qing Chang & Qian Chen

  2. Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai Medical School, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai, 200031, China

    Lili Zhang, Ting Zhang, Gezhi Xu, Chaoran Zhang, Jiang Qian, Qing Chang & Qian Chen

  3. Department of Pathology, Shanghai Medical School, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai, 200031, China

    Yingwen Bi

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  1. Lili Zhang
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Contributions

Qian Chen, Yingwen Bi, and Gezhi Xu: conceptualization, supervision, and manuscript review. Lili Zhang and Ting Zhang: data curation and analysis and writing the original draft. Chaoran Zhang, Qing Chang, and Jiang Qian: supervision. All authors approved the final version of the manuscript.

Corresponding authors

Correspondence to Yingwen Bi or Qian Chen.

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Ethical approval

The human ethics committee of the Eye, Ear, Nose, and Throat Hospital of Fudan University approved this retrospective review of existing medical records in accordance with the principles of the Declaration of Helsinki.

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Informed consent was obtained from all participants in the study.

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The authors declare no competing interests.

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Zhang, L., Zhang, T., Xu, G. et al. Multipurpose ultrasonographic characteristics of primary uveal MALT lymphoma. Graefes Arch Clin Exp Ophthalmol 261, 2383–2394 (2023). https://doi.org/10.1007/s00417-022-05958-2

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