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Impact of optical coherence tomography angiography on the non-invasive diagnosis of neovascular age-related macular degeneration

  • Retinal Disorders
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Abstract

Purpose

To investigate the changes in imaging tool practice for the diagnosis of neovascular age-related macular degeneration (nAMD).

Methods

Retrospective analysis of consecutive patients diagnosed with nAMD in a tertiary care center, over a 6-month period in 2014, 2016, and 2018. Patient demographics were compared. Imaging modalities used in 2014 were fundus photography, fluorescein angiography (FA), and structural spectral-domain optical coherence tomography (SD-OCT), while OCT-angiography (OCT-A) was available from 2015. Imaging tools used in our practice were compared in the 3 cohorts.

Results

The 3 cohorts included 163, 99, and 167 patients, respectively. There was no difference in age or gender (mean age 81.7 years). OCT-A images were analyzable in 60.5% and 89.7% of patients respectively in 2016 and in 2018. In the 3 cohorts, all patients were imaged with fundus photography and structural OCT. FA was performed in 70.2, 28.8, and 22.1% of patients, respectively.

Conclusion

This study showed a shift in practice of imaging tools used for the diagnosis of nAMD, non-invasive tools being increasingly used as the first-line imaging, and FA as the second-line imaging.

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Funding

No external funding was received for this research. The study was supported by CIL-ASSOC, association for research and education, Paris, France.

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Authors and Affiliations

  1. Department of Ophthalmology, Hôpital Avicenne, AP-HP and University Paris 13, Bobigny, France

    Audrey Giocanti-Auregan

  2. Ophthalmology Center for Imaging and Laser, Paris, France

    Lise Dubois, Pauline Dourmad & Salomon Y. Cohen

  3. Department of Ophthalmology, University of Paris Est, Creteil, France

    Salomon Y. Cohen

  4. Centre Ophtalmologique d’Imagerie et de Laser, 11 Rue Antoine Bourdelle, 75015, Paris, France

    Salomon Y. Cohen

Authors
  1. Audrey Giocanti-Auregan
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  2. Lise Dubois
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  3. Pauline Dourmad
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  4. Salomon Y. Cohen
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Corresponding author

Correspondence to Salomon Y. Cohen.

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Conflict of interest

Audrey Giocanti-Auregan is consultant for Allergan, Bayer, Novartis, and Optos Plc. Lise Dubois and Pauline Dourmad have no conflict of interest. Salomon Y Cohen is consultant for Allergan, Bayer, Novartis, Roche, Thea, and Tilak.

Ethical approval

All procedures performed in this study involving humans were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent is not required for this retrospective study. A favorable opinion for the conduct of the study was obtained from the Ethical Committee of the Federation France Macula.

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Giocanti-Auregan, A., Dubois, L., Dourmad, P. et al. Impact of optical coherence tomography angiography on the non-invasive diagnosis of neovascular age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 258, 537–541 (2020). https://doi.org/10.1007/s00417-019-04581-y

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  • DOI: https://doi.org/10.1007/s00417-019-04581-y

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