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Non-invasive measurements of the dynamic changes in the ciliary muscle, crystalline lens morphology, and anterior chamber during accommodation with a high-resolution OCT

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Abstract

Purpose

The purpose of the study was to assess non-invasively the changes in the anterior chamber eye, crystalline lens morphology, and ciliary muscle during accommodation by means of an anterior chamber optical coherence tomographer (OCT), and correlate them with vergence.

Methods

Twenty-five eyes of twenty-five healthy subjects, whose mean age was 29.9±7.1 years, were included and measured with an anterior chamber OCT. The central corneal thickness (CCT), anterior chamber depth (ACD), anterior crystalline lens radius of curvature (ALRC), crystalline lens thickness (CLT), and ciliary muscle area (CMA) were measured for each participant at 0, –1, –2, and –3 D of target vergence. A linear model was used to assess the correlation of each eye parameter with the vergence demand.

Results

The mean CCT showed no change for all the accommodative stimuli. The mean ACD and ALRC decreased with the vergence, about 4.5 and 30 % at –3 D, respectively. On the contrary, the CLT and CMA showed an opposite tendency, where the mean CLT was increased by 4.0 % and the mean CMA was done by 26% at –3 D. Statistical significant differences (p < 0.001) were obtained among all vergences for each eye metric, except for the CCT (p = 0.76).

Conclusion

The ACD and ALRC decreased about 2 and 10 % per dioptre of accommodation, respectively; whereas the CLT and CMA increased about 2 and 9 %, respectively. These results add knowledge regarding the understanding of accommodation and give new perspectives for biomechanics and biometry.

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Authors and Affiliations

  1. Department of Optics and Optometry and Vision Sciences, University of Valencia, C/ Dr Moliner, 50, 46100, Burjassot, Spain

    José J. Esteve-Taboada, Alberto Domínguez-Vicent, Daniel Monsálvez-Romín, Antonio J. Del Águila-Carrasco & Robert Montés-Micó

Authors
  1. José J. Esteve-Taboada
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  2. Alberto Domínguez-Vicent
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  3. Daniel Monsálvez-Romín
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  4. Antonio J. Del Águila-Carrasco
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  5. Robert Montés-Micó
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Corresponding author

Correspondence to Alberto Domínguez-Vicent.

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Funding

Authors acknowledge financial support from the Ministerio de Economía y Competitivad (Research Project SAF2013-44510-R with ERDF Funds from the European Union), a University of Valencia research scholarship (UV-INV-PREDOC13-110412) awarded to Alberto Domínguez-Vicent, a University of Valencia research scholarship (UV-INV-PREDOC14-179135) awarded to Antonio J. Del Águila-Carrasco, and a Ministerio de Educación, Cultura y Deporte research scholarship (FPU13/05332) awarded to Daniel Monsálvez-Romín. These sponsors had no role in the design or conduct of this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Esteve-Taboada, J.J., Domínguez-Vicent, A., Monsálvez-Romín, D. et al. Non-invasive measurements of the dynamic changes in the ciliary muscle, crystalline lens morphology, and anterior chamber during accommodation with a high-resolution OCT. Graefes Arch Clin Exp Ophthalmol 255, 1385–1394 (2017). https://doi.org/10.1007/s00417-017-3663-4

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  • DOI: https://doi.org/10.1007/s00417-017-3663-4

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