Abstract
Purpose
The objective of this study was to evaluate serum omentin, resistin and tumour necrosis factor-α (TNF-α) levels in Behcet disease (BD) patients with and without ocular involvement, as well as control subjects.
Methods
Omentin, resistin and TNF-α levels were assessed in the plasma of 51 BD patients and compared with those of 24 control subjects.
Results
The plasma resistin and TNF-α levels were significantly higher in the BD patients than in the control group (p = 0.028 and p = 0.011, respectively), whereas the plasma omentin level was significantly lower in BD patients than in the control group (p = 0.035). In the ocular BD, non-ocular BD and control groups, the omentin levels were 8.9 ± 4.65, 8.6 ± 3.61, and 12.4 ± 6.24 ng/mL; resistin levels were 0.29 ± 0.21, 0.24 ± 0.2 and 0.15 ± 0.45 ng/mL; and TNF-α levels were 25.45 ± 3.65, 24.03 ± 2.49 and 21.93 ± 4.86 ng/mL, respectively. Omentin/resistin and TNF-α/omentin ratios were more significant parameters in the demonstration of the differences in the groups; the former was lower and the latter was higher in the patient groups (p = 0.001 and p = 0.002, respectively).
Conclusions
We demonstrated that the plasma omentin level and omentin/resistin ratio were decreased, whereas the resistin and TNF-α levels and TNF-α/omentin ratio were increased in BD patients. These ratios may be used in the presentation of deviation in the inflammatory and anti-inflammatory balance in BD.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Geri G, Terrier B, Rosenzwajg M et al (2011) Critical role of IL-21 in modulating TH17 and regulatory T cells in Behcet disease. J Allergy Clin Immunol 128:655–664
Gürler A, Boyvat A, Türsen U (1997) Clinical manifestations of Behcet’s disease: an analysis of 2147 patients. Yonsei Med J 38:423–427
Tugal-Tutkun I, Onal S, Altan-Yaycioglu R, Huseyin Altunbas H, Urgancioglu M (2004) Uveitis in Behcet disease: an analysis of 880 patients. Am J Ophthalmol 138:373–380
Sayinalp N, Oezcebe OI, Oezdemir O, Haznedaroglu CH, Dundar S, Kirazli S (1996) Cytokines in Behcet’s disease. J Rheumatol 23:321–322
Imamura Y, Kurokawa MS, Yoshikawa H et al (2005) Involvement of Th1 cells and heat shock protein 60 in the pathogenesis of intestinal Behcet’s disease. Clin Exp Immunol 139:371–378
Direskeneli H, Fujita H, Akdis CA (2011) Regulation of TH17 and regulatory T cells in patients with Behcet disease. J Allergy Clin Immunol 128:665–666
Lehrke M, Reilly MP, Millington SC, Iqbal N, Rader DJ, Lazar MA (2004) An inflammatory cascade leading to Hyperresistinemia in humans. PLoS Med 1:e45
Pehlivan Y, Onat AM, Okumuş S et al (2012) The role of resistin in Behçet’s disease: a Turkish experiment. Mod Rheumatol 22:571–575
Yalçindag FN, Yalçindag A, Batioglu F, Caglayan O, Kisa U, Ozdemir O (2008) Evaluation of serum resistin levels in patients with ocular and non-ocular Behçet’s disease. Can J Ophthalmol 43:473–475
de Souza Batista CM, Yang RZ, Lee MJ et al (2007) Omentin plasma levels and gene expression are decreased in obesity. Diabetes 56:1655–1661
Zhong X, Li X, Liu F, Tan H, Shang D (2012) Omentin inhibits TNF-a-induced expression of adhesion molecules in endothelial cells via ERK/NF-jB pathway. Biochem Biophys Res Commun 425:401–406
Teles FR, Teles RP, Martin L, Socransky SS, Haffajee AD (2012) Relationships among IL-6, TNF-α, Adipokines, vitamin D and chronic periodontitis. J Periodontol 83:1183–1191
International Study Group for Behçet’s Disease (1990) Criteria for diagnosis of Behçet’s disease. Lancet 335:1078–1080
Mege JL, Dilsen N, Sanguedolce V et al (1993) Overproduction of monocyte derived TNF, interleukin (IL) 6, IL 8 and increased neutrophil superoxide generation in Behçet’s disease. A comparative study with familial Mediterranean fever and healthy subjects. J Rheumatol 20:1544–1549
Zhang M, Xu WD, Wen PF et al (2013) Polymorphisms in the tumor necrosis factor gene and susceptibility to Behcet’s disease: an updated meta-analysis. Mol Vis 19:1913–1924
Misumi M, Hagiwara E, Takeno M et al (2003) Cytokine production profile in patients with Behcet’s disease treated with infliximab. Cytokine 24:210–218
Pineton de Chambrun M, Wechsler B, Geri G, Cacoub P, Saadoun D (2012) New insights into the pathogenesis of Behçet’s disease. Autoimmun Rev 11:687–698
Karmiris K, Koutroubakis IE, Xidakis C, Polychronaki M, Voudouri T, Kouroumalis EA (2006) Circulating levels of leptin, adiponectin, resistin, and ghrelin in inflammatory bowel disease. Inflamm Bowel Dis 12:100–105
Senolt L, Housa D, Vernerova Z et al (2007) Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum. Ann Rheum Dis 66:458–463
Kim SK, Choe JY, Park SH, Lee SW, Lee GH, Chung WT (2010) Increased insülin resistance and serum resistin in Korean patients with Behçet’s disease. Arch Med Res 41:269–274
Yamawaki H, Kuramoto J, Kameshima S, Usui T, Okada M, Hara Y (2011) Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells. Biochem Biophys Res Commun 408:339–343
Kazama K, Usui T, Okada M, Hara Y, Yamawaki H (2012) Omentin plays an antiinflammatory role through inhibition of TNF-α-induced superoxide production in vascular smooth muscle cells. Eur J Pharmacol 686:116–123
Lu Y, Zhou L, Liu L et al (2014) Serum Omentin-1 as a disease activity marker for Crohn’s disease. Dis Markers 2014:162517. doi:10.1155/2014/162517
Ismail SA, Mohamed SA (2012) Serum levels of visfatin and omentin-1 in patients with psoriasis and their relation to disease severity. Br J Dermatol 167:436–439
Senolt L, Polanská M, Filková M et al (2010) Vaspin and omentin: new adipokines differentially regulated at the site of inflammation in rheumatoid arthritis. Ann Rheum Dis 69:1410–1411
Yamawaki H (2011) Vascular effects of novel adipocytokines: focus on vascular contractility and inflammatory responses. Biol Pharm Bull 34:307–310
Acknowledgments
We are grateful to Dicle University DUBAP for their sponsorship of the English editing of this manuscript.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.
This study was supported by the Scientific Research Fund of Dicle University. The authors have no financial interest in any of the products mentioned in the manuscript.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Türkcü, F.M., Şahin, A., Cingü, A.K. et al. Serum omentin, resistin and tumour necrosis factor-α levels in Behcet patients with and without ocular involvement. Graefes Arch Clin Exp Ophthalmol 253, 1565–1568 (2015). https://doi.org/10.1007/s00417-015-3016-0
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00417-015-3016-0