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Short-term variability of systemic blood pressure and submacular choroidal blood flow in eyes of patients with primary open-angle glaucoma

  • Glaucoma
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To analyse short-term variability of systemic blood pressure and choroidal blood flow in glaucoma patients, and compare them with ocular hypertensive patients and controls.

Subjects and methods

Thirty untreated patients with primary open-angle glaucoma (POAG), 25 untreated patients with ocular hypertension (OHT) and 50 healthy controls without local therapy were included in the study. Continuous 5-minute measurements of arterial systemic blood pressure (SBP) by Finometer and choroidal blood flow (CBF) by laser Doppler flowmetry were obtained. Variability of SBP and CBF was analysed by means of coefficient of variation and analyzed in ANOVA model. Linear regression analysis was performed on parameters of morphological (nerve fiber layer thickness) and functional glaucomatous damage (visual field) on one side, and between SBP and CBF on the other side.

Results

ANOVA model demonstrated significant differences in variability between the groups (p = 0.003); post-hoc analysis specified a significantly higher short-term variability of both the blood pressure and choroidal blood flow in POAG patients (coefficients of variation: 3.33% ± 1.05% and 3.90% ± 2.17% respectively) than in healthy controls (coefficient of variation: 2.57% ± 0.80% and 2.94% ± 1.52% respectively). No significant differences were found for OHT patients.

Conclusions

POAG patients without local therapy demonstrate an increased short-term BP and CBF variability.

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Authors and Affiliations

  1. Ophthalmology Department, University Hospital Basel, Mittlerestr. 91, CH-4031, Basel, Switzerland

    Asan Kochkorov, Konstantin Gugleta, Robert Katamay, Josef Flammer & Selim Orgul

Authors
  1. Asan Kochkorov
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  2. Konstantin Gugleta
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  3. Robert Katamay
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  4. Josef Flammer
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  5. Selim Orgul
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Corresponding author

Correspondence to Konstantin Gugleta.

Additional information

Asan Kochkorov and Konstantin Gugleta contributed equally.

Swiss National Foundation Grant 3200B0-113685, Velux Stiftung Grant, Freie Akademische Gesellschaft (FAG) Grant, Pfizer Inc. Grant

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Kochkorov, A., Gugleta, K., Katamay, R. et al. Short-term variability of systemic blood pressure and submacular choroidal blood flow in eyes of patients with primary open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol 248, 833–837 (2010). https://doi.org/10.1007/s00417-009-1277-1

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  • DOI: https://doi.org/10.1007/s00417-009-1277-1

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