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Real-time imaging of transscleral diode laser cyclophotocoagulation by optical coherence tomography

  • Clinical Investigation
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To present optical coherence tomography (OCT) for real-time imaging of cyclophotocoagulation effects.

Methods

In a pilot study, real-time transscleral OCT images were generated during diode laser cyclophotocoagulation in four eyes of four patients suffering from uncontrolled glaucoma using a specially designed contact applicator containing the OCT fiber, a focussing fiber optic and the fiber of the diode laser.

Results

When the contact system was used, two layers could be differentiated: a superficial thick hyperreflective complex representing conjunctiva, Tenon’s capsule, episclera and sclera, and a thinner hyporeflective layer representing the ciliary body. During cyclophotocoagulation, real-time OCT showed a clear and sudden thickening of the ciliary body in the treated area.

Conclusion

This new OCT device represents a first step towards visual, real-time imaging of cyclophotocoagulation. After further adaptation of the delivery system, further trials are needed to correlate OCT findings with aqueous production and intraocular pressure.

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References

  1. Benning H, Pfeiffer N (1995) Therapeutic range in transscleral contact cyclophotocoagulation. German J Ophthalmol 4:11–15

    CAS  Google Scholar 

  2. Bhola RM, Prasad S, McCormick AG, Rennie IG, Talbot JF, Parsons MA (2002) Pupillary distortion and staphyloma following trans-scleral contact diode laser cyclophotocoagulation: a clinicopathological study of three patients. Eye 16:674

    Article  Google Scholar 

  3. Brancato R, Carassa RG (1996) Value of ultrasound biomicroscopy for ciliodestructive procedures. Curr Opin Ophthalmol 7:87–92

    Article  PubMed  CAS  Google Scholar 

  4. Brancato R, Pratesi R (1987) Application of diode laser in ophthalmology. Laser Ophthalmol 1:119–129

    Google Scholar 

  5. Brancato R, Carassa RG, Bettin P, Flori M, Trabucchi G (1995) Contact transscleral cyclophotocoagulation with diode laser in refractory glaucoma. Eur J Ophthalmol 5:32–39

    PubMed  CAS  Google Scholar 

  6. Egbert PR, Fiadoyor S, Budenz DL, Dadzie P, Byrd S (2001) Diode laser cyclophotocoagulation as a primary surgical treatment for primary open-angle glaucoma. Arch Ophthamol 119:345–350

    CAS  Google Scholar 

  7. Fujimoto JG, Brezinski ME, Tearney GJ, Boppart SA, Bouma B, Hee MR, Southern JF, Swanson EA (1995) Optical biopsy and imaging using optical coherence tomography. Nature Med 1:970–972

    Article  PubMed  CAS  Google Scholar 

  8. Gaasterland DE (1992) A multicenter study of contact diode laser transscleral cyclophotocoagulation in glaucoma patients. Invest Ophthalmol Vis Sci 33:1644

    Google Scholar 

  9. Hawkins TA, Steward CS (1993) One-year result of semiconductor transscleral cyclophotocoagulation in patients with glaucoma. Arch Ophthalmol 111:488–491

    PubMed  CAS  Google Scholar 

  10. Hennis HL, Stewart WC (1992) Semiconductor diode laser transscleral cyclophotocoagulation in patients with glaucoma. Am J Ophthalmol 113:81–85

    PubMed  CAS  Google Scholar 

  11. Hennis HL, Asia E, Stewart WC, Legler UFC, Apple DJ (1991) Transscleral cyclophotocoagulation using a semiconductor diode laser in cadaver eyes. Ophthalmic Surg 22:1–5

    Google Scholar 

  12. Hoerauf H, Wirbelauer C, Scholz C, Engelhardt R, Koch P, Laqua H, Birngruber R (2000) Slitlamp adapted optical coherence tomography (OCT) of the anterior segment. Graefe’s Arch Clin Exp Ophthalmol 238:8–18

    Article  CAS  Google Scholar 

  13. Hoerauf H, Gordes RS, Scholz C, Koch P, Engelhardt R, Wirbelauer C, Laqua H, Birngruber R (2000) First experimental and clinical results with transscleral optical coherence tomography. Ophthalmic Surg Lasers 31:218–222

    PubMed  CAS  Google Scholar 

  14. Hoerauf H, Scholz C, Koch P, Engelhardt R, Laqua H, Birngruber R (2002) Transscleral optical coherence tomography - a new imaging method for the anterior segment of the eye. Arch Ophthalmol 120:816–819

    PubMed  Google Scholar 

  15. Hoerauf H, Winkler J, Scholz C, Wirbelauer C, Gordes RS, Koch P, Engelhardt R, Laqua H, Birngruber R (2002) Transscleral optical coherence tomography - an experimental study in ex-vivo human eyes. Lasers Surg Med 30:209–215

    Article  PubMed  Google Scholar 

  16. Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, Hee MR, Flotte T, Gregory K, Puliafito CA, Fujimoto JG (1991) Optical coherence tomography. Science 254:1178–1181

    Article  PubMed  CAS  Google Scholar 

  17. Izatt JA, Hee MR, Swanson EA, Lin CP, Huang D, Schuman JS, Puliafito CA, Fujimoto JG (1994) Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography. Arch Ophthalmol 112:1584–1589

    PubMed  CAS  Google Scholar 

  18. Izatt JA, Rollins AM, Yazdanfar S (2000) Real-time optical coherence tomography of the anterior segment. Invest Ophthalmol Vis Res 41:675

    Google Scholar 

  19. Pavlin CJ, Foster FS (1995) Ultrasound biomicroscopy of the eye. Springer, Berlin Heidelberg New York

    Google Scholar 

  20. Pavlin CJ, Harasiewicz K, Sherar MD, Foster FS (1991) Clinical use of ultrasound biomicroscopy. Ophthalmology 98:287–295

    PubMed  CAS  Google Scholar 

  21. Pavlin CJ, Macken P, Trope GE, Heathcote G, Shear M, Harasiewicz K, Foster SF (1995) Ultrasound biomicroscopy imaging of the effects of YAG laser cyclophotocoagulation in postmortem eyes and living patients. Ophthalmology 102:334–341

    PubMed  CAS  Google Scholar 

  22. Preuβner P-R (1998) Kontrollierte Zyklophotokoagulation. Ophthalmologe 95:645–650

    Article  PubMed  Google Scholar 

  23. Preuβner P-R, Boos N, Fassbender K, Schwenn O, Pfeiffer N (1997) Real-time control for transscleral cyclophotocoagulation. Graefe’s Arch Clin Exp Ophthalmol 235:794–801

    Article  Google Scholar 

  24. Radhakrishnan S, Reeves D, Lass JH, Szczotka LB, Westphal V, Roth JE, Izatt JA (2001) Real-time optical coherence tomography of the anterior chamber angle. Invest Ophthalmol Vis Res 42:791

    Google Scholar 

  25. Rosenow S-E et al (1999) Cyclophotocoagulation: experimental investigations of dosage problems. Graefe’s Arch Clin Exp Ophthalmol 237:583–592

    Article  CAS  Google Scholar 

  26. Schlote T, Derse M, Thiel H-J, Jean B (2000) Pupillary distortion after contact transscleral diode laser cyclophotocoagulation. Br J Ophthalmol 84:337–340

    Article  PubMed  CAS  Google Scholar 

  27. Schlote T, Derse M, Zierhut M (2000) Transscleral diode laser cyclophotocoagulation for the treatment of refractory glaucoma secondary to inflammatory eye diseases. Br J Ophthalmol 84:999–1003

    Article  PubMed  CAS  Google Scholar 

  28. Schlote T, Derse M, Rassmann K, Nicaeus T, Dietz K, Thiel HJ (2001) Efficacy and safety of contact transscleral diode laser cyclophotocoagulation for advanced glaucoma. J Glaucoma 10:294–301

    Article  PubMed  CAS  Google Scholar 

  29. Schumann JS, Noecker RJ, Puliafito CA, Jacobson JJ, Sheps GJ, Wang N (1991) Energy levels and probe placement in contact transscleral semiconductor diode laser cyclophotocoagulation in human cadaver eyes. Arch Ophthalmol 109:1534–1538

    Google Scholar 

  30. Silvermann RH, Rondeau MJ, Lizzi FL, Coleman DJ (1994) Three-dimensional high-frequency ultrasonic parameter imaging of anterior segment pathology. Ophthalmology 102:837–843

    Google Scholar 

  31. Simmons RB, Prum BE, Shields SR, Echelmann DA, Shields MB (1993) Videographic and histologic comparison of Nd:YAG and diode laser contact transscleral cyclophotocoagulation. Am J Ophthalmol 117:337–341

    Google Scholar 

  32. Stolzenburg S, Müller-Stolzenburg N, Kresse S, Müller GJ (1992) Optimierung der Koagulationsparameter. Ophthalmologe 89:210–217

    PubMed  CAS  Google Scholar 

  33. Toth CA, Birngruber R, Boppart SA, Hee MR, Fujimoto JG, DiCarlo CD, Swanson EA, Cain CP, Narayan DG, Noojin GD, Roach WP (1997) Argon laser retinal lesions evaluated in vivo by optical coherence tomography. Am J Ophthalmol 123:188–198

    PubMed  CAS  Google Scholar 

  34. Vesti E, Rong-Guang W, Raitta C (1992) Transillumination guided cyclocryotherapy in the treatment of secondary glaucoma. Eur J Ophthalmol 2:190–195

    Google Scholar 

  35. Vogel A, Dlugos C, Nuffer R, Birngruber R (1991) Die optischen Eigenschaften der menschlichen Sklera und deren Bedeutung für transsklerale Laseranwendungen. Fortschr Ophthalmol 88:754–761

    PubMed  CAS  Google Scholar 

  36. Werner RG, Vick HP, Guthoff R (1998) Zyklophotokoagulation mit dem Diodenlaser. Ophthalmologe 95:176–180

    Article  PubMed  CAS  Google Scholar 

  37. Wirbelauer C, Scholz C, Hoerauf, H, Engelhardt R, Birngruber R, Laqua H (2000) Corneal optical coherence tomography before and immediately after excimer laser photorefractive keratectomy. Am J Ophthalmol 130:693–699

    Article  PubMed  CAS  Google Scholar 

  38. Zeyen T, Vandenberghe K (2004) Miscalibration and severe complications after diode laser cyclophotocoagulation: two case reports. Bull Soc Belge Ophtalmol 292:27–30

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Medical University Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany

    H. Hoerauf & M. Müller

  2. Institute for Biomedical Optics, Lübeck, Germany

    G. Hüttmann & C. Winter

  3. Department of Ophthalmology, Clinic Pallas, Olten, Switzerland

    T. Schlote

Authors
  1. H. Hoerauf
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  2. M. Müller
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  3. G. Hüttmann
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  4. C. Winter
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  5. T. Schlote
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Corresponding author

Correspondence to H. Hoerauf.

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The authors have no commercial or financial interest in the study.

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Hoerauf, H., Müller, M., Hüttmann, G. et al. Real-time imaging of transscleral diode laser cyclophotocoagulation by optical coherence tomography. Graefe's Arch Clin Exp Ophthalmol 245, 385–390 (2007). https://doi.org/10.1007/s00417-006-0421-4

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  • DOI: https://doi.org/10.1007/s00417-006-0421-4

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