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Different independent susceptibility markers for first-ever cerebral infarction and myocardial infarction in young patients

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Abstract

Cerebral infarction (CI) and myocardial infarction (MI) share some common features, but there are other differences in risk factors. The aim of our study is to determine whether there are some significantly independent susceptibility markers for them. All consecutive patients between the ages of 18 and 45 years with first-ever CI and MI during 2001–2010 were recruited to participate in the study. Using multivariate logistic regression modeling, we explore many different data, such as age at onset, sex ratio, numbers of patients with history of hypertension, smoking, drinking, and serum lipid, uric acid, prealbumin (PA), and white blood cell (WBC) count levels. Logistic regression analysis adjusted for confounders confirmed the following independent susceptibility markers for young CI patients: hypertension, admission serum PA levels, daily alcohol [odds ratio (OR), 0.251; 95% confidence interval (CI), 0.097–0.648, p = 0.004; OR, 0.994; 95% CI, 0.988–0.999, p = 0.031; OR, 0.150; 95% CI, 0.047–0.473, p = 0.001], and for MI patients: age at onset, current smoking, serum WBC, and glucose levels (OR, 1.293; 95% CI, 1.146–1.457, p = 0.000; OR, 8.914; 95% CI, 3.575–22.231, p = 0.000; OR, 1.344; 95% CI, 1.169–1.544, p = 0.000; OR, 1.149; 95% CI, 1.022–1.291, p = 0.020). We conclude that there are some significantly different independent susceptibility markers for young CI and MI patients.

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Acknowledgments

This study was supported by grant Guangdong Provincial Science and Technology Program, grant 2009B030801363 and Guangzhou pearl rivers science and technology star plan, 2012017.

Conflicts of interest

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province, The Ministry of Education of China, Institute of Neuroscience, The Second Affiliated Hospital of GuangZhou Medical University, 250# Changgang East Road, GuangZhou, 510260, Guangdong Province, China

    Bin Zhang, Cong Gao, Qinghua Hou, Jianrui Yin, Longchang Xie, Shuxiang Pu, Yonghong Yi & Qingchun Gao

  2. Department of Neurology, The Second Affiliated Hospital of GuangZhou Medical University, 250# Changgang East Road, GuangZhou, 510260, Guangdong Province, China

    Bin Zhang, Cong Gao, Qinghua Hou, Jianrui Yin, Longchang Xie, Shuxiang Pu, Yonghong Yi & Qingchun Gao

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  1. Bin Zhang
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  2. Cong Gao
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  3. Qinghua Hou
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  4. Jianrui Yin
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Correspondence to Cong Gao.

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Bin Zhang and Cong Gao are the co-first authors.

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Zhang, B., Gao, C., Hou, Q. et al. Different independent susceptibility markers for first-ever cerebral infarction and myocardial infarction in young patients. J Neurol 259, 1420–1425 (2012). https://doi.org/10.1007/s00415-011-6368-3

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  • DOI: https://doi.org/10.1007/s00415-011-6368-3

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