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Management of punding in Parkinson’s disease: an open-label prospective study

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Abstract

Punding, a peculiar stereotyped behavior characterized by intense fascination with complex, excessive, non-goal-oriented, repetitive activities, is a quite rare condition complicating Parkinson’s disease (PD). It is triggered by dopaminergic therapy and could have a strong impact on patient quality of life. No study has specifically investigated medical management of this condition, and only a few anecdotal reports have provided therapeutic hints. Given the suggested similarities to drug-induced dyskinesias, we have previously suggested a multistep algorithm for management of punding. We conducted a prospective open-label study on ten PD punders aimed at testing its validity. In two cases, reduction of levodopa therapy was efficacious; amantadine was effective in controlling punding in four cases; in the remaining cases, quetiapine was employed, with mild efficacy in two cases.

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Abbreviations

PD:

Parkinson’s disease

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Conflict of interest

The authors declare that they have no conflict of interest or financial disclosures.

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Authors and Affiliations

  1. Istituto di Neurologia, Università Cattolica del Sacro Cuore Largo Agostino Gemelli, 8, 00168, Rome, Italy

    A. Fasano & A. R. Bentivoglio

  2. Neuromed Institute, Pozzilli, IS, Italy

    A. Fasano

  3. Department of Neurosciences, Psychiatry and Anaesthesiological Science, University of Messina, Messina, Italy

    L. Ricciardi

  4. Department of Psychiatry, Catholic University of Sacred Heart, Rome, Italy

    M. Pettorruso

Authors
  1. A. Fasano
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  2. L. Ricciardi
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  3. M. Pettorruso
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  4. A. R. Bentivoglio
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Corresponding author

Correspondence to A. Fasano.

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Fasano, A., Ricciardi, L., Pettorruso, M. et al. Management of punding in Parkinson’s disease: an open-label prospective study. J Neurol 258, 656–660 (2011). https://doi.org/10.1007/s00415-010-5817-8

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  • DOI: https://doi.org/10.1007/s00415-010-5817-8

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