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Cerebral metabolic correlates of four dementia scales in Alzheimer’s disease

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The Original Article was published on 23 February 2005

Abstract

Different scales can be used to evaluate dementia severity in Alzheimer’s disease (AD). They do assess different cognitive or functional abilities, but their global scores are frequently in mutual correlation. Functional imaging provides an objective method for the staging of dementia severity. Positron emission tomography was used to assess the relationship between brain metabolism and four dementia scales that reflect a patient’s global cognitive abilities (mini mental state), caregiver’s evaluation of cognitive impairment (newly designed scale), daily living functioning (instrumental activities of daily living) and global dementia (clinical dementia rating). We wondered whether different clinical dementia scales would be related to severity of metabolic impairment in the same brain regions, and might reflect impairment of common cognitive processes. 225 patients with probable AD were recruited in a prospective multicentre European study. All clinical scales were related to brain metabolism in associative temporal, parietal or frontal areas. A factorial analysis demonstrated that all scales could be classified in a single factor. That factor was highly correlated to decrease of cerebral activity in bilateral parietal and temporal cortices, precuneus, and left middle frontal gyrus. This finding suggests that global scores for all scales provided similar information on the neural substrate of dementia severity. Capitalizing on the neuroimaging literature, dementia severity reflected by reduced metabolism in posterior and frontal associative areas in AD might be related to a decrease of controlled processes.

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Authors and Affiliations

  1. Department of Neurology, University Cologne, Cologne

    K. Herholz & E. Kalbe

  2. Max-Planck Institute for Neurological Research, Josel-Stelzmann-Str 9, 50931, Cologne, Germany

    K. Herholz & E. Kalbe

  3. Vita Salute San Raffaele University, Institute of Bioimaging and Molecular Physiology CNR, IRCC H San Raffaele, Milan, Italy

    D. Perani & D. Anchisi

  4. Department of Psychiatry and Psychotherapy, Dresden University of Technology, Fletscherstr 74, 01307, Dresden, Germany

    V. Holthoff

  5. Cyclotron Research Centre, University of Liege, B30 Sart Tilman, 4000, Liege, Belgium

    E. Salmon*, S. Lespagnard*, P. Marique, F. Peeters, S. Adam, F. Collette & G. Garraux

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  1. E. Salmon*
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Corresponding author

Correspondence to E. Salmon*.

Additional information

Affiliation of D. Perani and D. Anchisi has been incompletely published. The original article can be found online at http://dx.doi.org/10.1007/s00415-005-0551-3

The publisher apologises for any inconvenience caused by this mistake.

*Both authors contributed equally to this paper.

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Salmon*, E., Lespagnard*, S., Marique, P. et al. Cerebral metabolic correlates of four dementia scales in Alzheimer’s disease. J Neurol 252, 1138 (2005). https://doi.org/10.1007/s00415-005-0961-2

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  • DOI: https://doi.org/10.1007/s00415-005-0961-2

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