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Associations of TIM-1 Genetic Polymorphisms with Asthma: A Meta-analysis

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Abstract

Purpose

Recently, the roles of TIM-1 genetic polymorphisms in asthma have been extensively studied, with conflicting results. Therefore, we performed the present meta-analysis to better assess potential associations of TIM-1 genetic polymorphisms with asthma.

Methods

Eligible articles were searched in PubMed, Medline, EMBASE, Google Scholar, and CNKI up to December 2016. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to detect any potential associations between TIM-1 genetic polymorphisms and asthma.

Results

A total of 12 articles including 3120 asthma patients and 2825 control subjects were analyzed. The overall and subgroup analyses revealed that TIM-1-416G>C single nucleotide polymorphism was significantly associated with asthma for the Asian population in the codominant (G/G vs. G/C, p = 0.0003, OR 1.86, 95% CI 1.33–2.60) and dominant (G/G vs. G/C + C/C, p < 0.0001, OR 1.94, 95% CI 1.40–2.69) genetic models. Nevertheless, we failed to detect any significant associations between TIM-1-416G>C single nucleotide polymorphism and asthma in Caucasians. Additionally, according to our analyses, TIM-1 5383_5397 insertion/deletion polymorphism was not correlated with asthma in both Asians and Caucasians.

Conclusions

In conclusion, our findings suggest that TIM-1-416G>C single nucleotide polymorphism is associated with asthma susceptibility for the Asian ethnicity in certain genetic models. However, TIM-1 5383_5397 insertion/deletion polymorphism may not be correlated with the risk of asthma.

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References

  1. Bousquet J, Humbert M (2015) GINA 2015: the latest iteration of a magnificent journey. Eur Respir J 46:579–582

    Article  PubMed  Google Scholar 

  2. Pawankar R, Canonica GW, Holgate ST, Lockey RF (2012) Allergic diseases and asthma: a major global health concern. Curr Opin Allergy Clin Immunol 12:39–41

    Article  PubMed  Google Scholar 

  3. Ober C, Yao TC (2011) The genetics of asthma and allergic disease: a 21st century perspective. Immunol Rev 242:10–30

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Zhang Y, Moffatt MF, Cookson WO (2012) Genetic and genomic approaches to asthma: new insights for the origins. Curr Opin Pulm Med 18:6–13

    Article  PubMed  Google Scholar 

  5. Wills-Karp M, Ewart SL (2004) Time to draw breath: asthma susceptibility genes are identified. Nat Rev Genet 5:376–387

    Article  CAS  PubMed  Google Scholar 

  6. Freeman GJ, Casasnovas JM, Umetsu DT, DeKruyff RH (2010) TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol Rev 235:172–189

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Khademi M, Illés Z, Gielen AW et al (2004) T Cell Ig- and mucin domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. J Immunol 172:7169–7176

    Article  CAS  PubMed  Google Scholar 

  8. Meyers JH, Sabatos CA, Chakravarti S, Kuchroo VK (2005) The TIM gene family regulates autoimmune and allergic diseases. Trends Mol Med 11:362–369

    Article  CAS  PubMed  Google Scholar 

  9. Kuchroo VK, Umetsu DT, DeKruyff RH, Freeman GJ (2003) The TIM gene family: emerging roles in immunity and disease. Nat Rev Immunol 3:454–462

    Article  CAS  PubMed  Google Scholar 

  10. Chae SC, Song JH, Heo JC et al (2003) Molecular variations in the promoter and coding regions of human Tim-1 gene and their association in Koreans with asthma. Hum Immunol 64:1177–1182

    Article  CAS  PubMed  Google Scholar 

  11. Chen JP, Zhao WL, He NH et al (2012) Association of hepatitis A exposure and TIM-1 with childhood allergic asthma. J Asthma 49:697–702

    Article  CAS  PubMed  Google Scholar 

  12. Liu Q, Shang L, Li J et al (2007) A functional polymorphism in the TIM-1 gene is associated with asthma in a Chinese Han population. Int Arch Allergy Immunol 144:197–202

    Article  CAS  PubMed  Google Scholar 

  13. Mete F, Ozkaya E, Aras S et al (2014) Association between gene polymorphisms in TIM1, TSLP, IL18R1 and childhood asthma in Turkish population. Int J Clin Exp Med 7:1071–1077

    PubMed  PubMed Central  Google Scholar 

  14. Shirzade H, Meshkat R, Ganjalikhani-Hakemi M et al (2015) Association analysis of -416 G > C polymorphism of T-cell immunoglobulin and mucin domain-1 gene with asthma in Iran. Int J Immunogenet 42:265–269

    Article  CAS  PubMed  Google Scholar 

  15. Sinha S, Singh J, Jindal SK (2015) Protective association of TIM1-1454G>A Polymorphism with asthma in a North Indian population. Lung 193:31–38

    Article  CAS  PubMed  Google Scholar 

  16. Chae SC, Song JH, Lee YC et al (2003) The association of the exon 4 variations of Tim-1 gene with allergic diseases in a Korean population. Biochem Biophys Res Commun 312:346–350

    Article  CAS  PubMed  Google Scholar 

  17. Cui TP, Jin J, Liu CY et al (2004) Exploring the possibility of a relationship between polymorphism in TIM-1 and allergic asthma in children of the Hans from Hubei province of China. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 21:403–406

    CAS  PubMed  Google Scholar 

  18. Gao PS, Mathias RA, Plunkett B et al (2005) Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population. J Allergy Clin Immunol 115:982–988

    Article  CAS  PubMed  Google Scholar 

  19. Li JS, Liu QJ, Wang P et al (2006) Absence of association between two insertion/deletion coding genetic polymorphisms of TIM-1 gene and asthma in Chinese Han population. Int J Immunogenet 33:417–422

    Article  CAS  PubMed  Google Scholar 

  20. Wu Q, Hu L, Cai P, Chen F, Kong L (2009) Association analysis of TIM-1-232G>A and 5383_5397 insertion/deletion polymorphisms with childhood asthma and total serum immunoglobulin E levels in middle China. J Investig Allergol Clin Immunol 19:146–153

    CAS  PubMed  Google Scholar 

  21. Xu J, Jiang P, Liu J (2014) Pooled analysis of the association between TIM-1 5383_5397 insertion/deletion polymorphism and asthma susceptibility. Mol Biol Rep 41:7825–7831

    Article  CAS  PubMed  Google Scholar 

  22. Doull IJ, Lawrence S, Watson M et al (1996) Allelic association of gene markers on chromosomes 5q and 11q with atopy and bronchial hyperresponsiveness. Am J Respir Crit Care Med 153:1280–1284

    Article  CAS  PubMed  Google Scholar 

  23. Noguchi E, Shibasaki M, Arinami T, Takeda K, Maki T, Miyamoto T (1997) Evidence for linkage between asthma/atopy in childhood and chromosome 5q31-q33 in a Japanese population. Am J Respir Crit Care Med 156:1390–1393

    Article  CAS  PubMed  Google Scholar 

  24. Shek LP, Tay AH, Chew FT, Goh DL, Lee BW (2001) Genetic susceptibility to asthma and atopy among Chinese in Singapore-linkage to markers on chromosome 5q31-33. Allergy 56:749–753

    Article  CAS  PubMed  Google Scholar 

  25. Umetsu SE, Lee WL, McIntire JJ et al (2005) TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Nat Immunol 6:447–454

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (81270289, 81300169).

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Authors and Affiliations

  1. Department of Cardiology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, People’s Republic of China

    Xiaochuan Xie & Li Rao

  2. Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital of Sichuan University, Chengdu, 610041, Sichuan, People’s Republic of China

    Xiaohan Shi

  3. Laboratory of Molecular Translational Medicine, West China Second University Hospital of Sichuan University, Chengdu, 610041, Sichuan, People’s Republic of China

    Peng Chen

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  1. Xiaochuan Xie
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  2. Xiaohan Shi
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  3. Peng Chen
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  4. Li Rao
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Correspondence to Li Rao.

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Conflict of interest

The authors report no conflict of interest regarding the content herein.

Ethical Approval

All analyses in the present meta-analysis were based on the previous published studies; thus, no ethical approval and patient consent are required.

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Xie, X., Shi, X., Chen, P. et al. Associations of TIM-1 Genetic Polymorphisms with Asthma: A Meta-analysis. Lung 195, 353–360 (2017). https://doi.org/10.1007/s00408-017-0006-5

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