Abstract
Objective
Dysregulation of RNA binding proteins (RBPs) plays an important role in controlling processes in cancer development. However, the function of RBPs has not been thoroughly and systematically documented in head and neck cancer. We aim to explore the role of RPB in the pathogenesis of HNSC.
Methods
We obtained HNSC gene expression data and corresponding clinical information from The Cancer Genome Atlas (TCGA) and the GEO databases, and identified aberrantly expressed RBPs between tumors and normal tissues. Meanwhile, we performed a series of bioinformatics to explore the function and prognostic value of these RBPs.
Results
A total of 249 abnormally expressed RBPs were identified, including 101 downregulated RBPs and 148 upregulated RBPs. Using least absolute shrinkage and selection operator (LASSO) and univariate Cox regression analysis, the 15 RPBs were identified as hub genes. With the 15 RPBS, the prognostic prediction model was constructed. Further analysis showed that the high-risk score of the patients expressed a better survival outcome. The prediction model was validated in another HNSC dataset, and similar findings were observed.
Conclusions
Our results provide novel insights into the pathogenesis of HNSC. The fifteen RBP gene signature exhibited the predictive value of moderate HNSC prognosis, and have potential application value in clinical decision-making and individualized treatment.
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Availability of data and material
Data availability could be obtained from TCGA website.
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Funding
The works were supported by Guizhou Science and Technology Department (Identification of Slug-regulated miRNA in oral squamous cell carcinoma and its mechanism of tumor metastasis inhibition, NO: Qiankehe LH [2014] No. 7012).
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JKS, XFD, XLC wrote the main manuscript text. JKS, KZ, XLC prepared Figs. 1–9. JKS, XFD contributed to data analysis. All authors reviewed the manuscript.
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Duan, X., Cheng, X., Yin, X. et al. Systematic analysis of the function and prognostic value of RNA binding protein in head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol 279, 1535–1547 (2022). https://doi.org/10.1007/s00405-021-06929-9
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DOI: https://doi.org/10.1007/s00405-021-06929-9