Abstract
Introduction
Tumor-infiltrating lymphocytes (TILs) have a recognized antitumor activity in head and neck squamous cell carcinoma (HNSCC). CD45 is one of the most highly expressed proteins in lymphocytes. We carry out a study to assess the prognostic value of transcriptional expression of CD45 in HNSCC.
Material and methods
We determined the transcriptional expression of CD45 in 160 consecutive HNSCC patients and compared the TIL values according to the CD45 expression.
Results
Five-year disease-free survival for patients with a high transcriptional expression of CD45 (n = 107) was 62.4% and for patients with a low expression (n = 53) it was 36.2% (P = 0.003). Patients with a high expression of CD45 had a better local recurrence-free survival and disease-specific survival. The results of a multivariate analysis showed that patients with a low expression of CD45 had 2.0-fold high risk of recurrence (95% CI 1.2–3.2, P = 0.003). In oropharyngeal carcinomas, HPV-positive tumors showed a higher transcriptional CD45 expression than HPV-negative tumors. Tumors with high CD45 expression had immunohistochemical TIL scores significantly higher than those with low CD45 expression.
Conclusion
According to our results, CD45 expression is a potential marker for tumor outcome in HNSCC patients.
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This work was supported by the Plan Estatal de I + D + I of the Instituto de Salud Carlos III (FIS PI14/01819 to XL, FIS PI15/02047 to FXAJ). Fondo Europeo de Desarrollo Regional (FEDER), A Way to Build Europe.
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The authors declare that they have no conflict of interest.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Due to the retrospective type of the study no formal consent was required.
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Camacho, M., Agüero, A., Sumarroca, A. et al. Prognostic value of CD45 transcriptional expression in head and neck cancer. Eur Arch Otorhinolaryngol 275, 225–232 (2018). https://doi.org/10.1007/s00405-017-4806-2
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DOI: https://doi.org/10.1007/s00405-017-4806-2