Abstract
The objective of this study is to assess the validity of ASSR as a complementary diagnostic test for peripheral hearing loss by proving a significant correlation between behavioral thresholds and ASSR. The design used in this study is monocentric prospective study from November 2014 to April 2015. The setting used in this study is the ENT—Head and Neck Surgery Department and Geriatrics Department in a French Regional and University Hospital. The participants are patients over 75 years with cognitive impairment (Alzheimer’s disease or mild-cognitive impairment) with a Mini-Mental State Examination score under 27/30 and without hearing aids. Exclusion criteria were: otoscopic and middle ear abnormalities, retro-cochlear lesion, other types of dementia, and central nervous system disease altering cerebral lateralization. The intervention used in this study is pure-tone audiometry, speech audiometry, dichotic listening test, and auditory steady-state responses recording. The correlations between these exams were studied with Pearson’s correlation coefficient and Student’s t test. Results were significant if p < 0.05. Twenty-three ears were analyzed from 12 patients. There were six women and six men with cognitive impairment, mean age 82.1 (±4.6) years, and mean MMSE score that was 21.3/30 (±5.7). The correlation between pure-tone audiometry and ASSR was significant for all frequencies: r = 0.55 (p = 0.006) for 500 Hz, r = 0.58 (p = 0.005) for 1000 Hz, r = 0.61 (p = 0.003) for 2000 Hz, and r = 0.66 (p = 0.002) for 4000 Hz. There was no significant correlation between the MMSE and the difference between ASSR and PTA on each frequency. The dichotic listening test showed a right ear advantage (50.9 %, p = 0.039). The ASSR in patients with cognitive impairment and understanding troubles is a promising complementary technique to estimate the hearing thresholds.
Similar content being viewed by others
References
Ferri CP, Prince M, Brayne C et al (2005) Global prevalence of dementia: a Delphi consensus study. Lancet 366:2112–2117
Reitz C, Brayne C, Mayeux R (2011) Epidemiology of Alzheimer disease. Nat Rev Neurol 7:137–152
McKhann GM et al (2011) The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging–Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7(3):263–269
Coley N, Andrieu S, Gardette V et al (2008) Dementia prevention: methodological explanations for inconscient results. Epidemiol Rev 30:35–66
Amieva H, Ouvrard C, Giulioli C et al (2015) Self-reported hearing loss, hearing aids, and cognitive decline in elderly adults: a 25-year study. JAGS. 63:10
Kutova M, Mrzilkova J, Kirdajova D et al (2014) Simple method for evaluation of planum temporale pyramidal neurons shrinkage in post-mortem tissue of Alzheimer disease patients. BioMed Res Int 607171:6
Jerger J (2001) Asymmetry in auditory function in elderly persons. Semin Hear 22:255–269
Sinha UK, Hollen KM, Rodriguez R et al (1993) Auditory system degeneration in Alzheimer’s disease. Neurology 43:779–785
Idrizbegovic E, Hederstierna C, Dahlquist M et al (2011) Central auditory function in early Alzheimer’s disease and in mild cognitive impairment. Age Aging 40:249–254
Hommet C, Mondon K, Berrut G et al (2010) Central auditory processing in aging: the dichotic listening paradigm. J Nutr Health Aging 14(9):751–756
Gates GA, Anderson ML, McCurry SM et al (2011) Central auditory dysfunction as a harbinger of Alzheimer dementia. Arch Otolaryngol Head Neck Surg 137:390–395
Gallacher J, Ilubaera V, Ben-Shlomo Y et al (2012) Auditory threshold, phonologic demand, and incident dementia. Neurology 79(15):1583–1590
Mulrow CD, Aguilar C, Endicott JE et al (1990) Association between hearing impairment and the quality of life of elderly individuals. J Am Geriatr Soc 38(1):45–50
Galambos R, Makeig S, Talmachoff PJ (1981) A 40 Hz auditory potential recorded from the human scalp. Proc Natl Acad Sci 78(4):2643–2647
Petersen RC, Aisen P, Boeve BF et al (2013) Mild cognitive impairment due to Alzheimer disease in the community. Ann Neurol 74(2):199–208
Duarte JL, Alvarenga KF, Garcia TM et al (2008) Auditory steady-state response in the auditory evaluation: clinical application. PrόFono Revista de Atualização 20(2):105–110
de Oliveira Miquelino, Beck R, Faria Ramos B, Schuster Grasel S et al (2014) Comparative study between pure tone audiometry and auditory steady-state responses in normal hearing subjects. Braz J Otorhinolaryngol 80(1):35–40
Dimitrijevic A, John MS, Van Roon P et al (2002) Estimating the audiogram using multiple auditory steady-state responses. J Am Acad Audiol 13:205–224
Jafari Z, Malayeri S, Ashayeri H et al (2009) Adults with auditory neuropathy: comparison of auditory steady state response and pure tone audiometry. J Am Acad Audiol 20(10):621–628
Ross B, Pantev C (2004) Auditory steady-state responses reveal amplitude modulation gap detection thresholds. J Acoust Soc Am 115(5):2193–2206
Burkard RF, Don M, Eggermont JJ (2006) Auditory evoked potentials—basic principles and clinical application. Lippincott, Williams and Wilkins, Philadelphia, 1st edition, p 454
Stapells DR (2011) Frequency-specific ABR and ASSR thresholds assessment in young infants. Comprehensive handbook of pediatric audiology. RC Seewald and AM Tharpe editions, Plural Publishing Inc, San Diego, p 409–448
Gates GA, Gibbons LE, McCurry SM et al (2010) Executive dysfunction and presbycusis in older persons with and without memory loss and dementia. Cogn Behav Neurol 23:218–223
Palmer CV, Adams SW, Bourgeois M et al (1999) Reduction in caregiver-identified problem behaviors in patients with Alzheimer disease post-hearing-aid fitting. J Speech Lang Hear Res 42(2):312–328
Bakhos D, Villeneuve A, Kim S et al (2015) Hearing loss and Alzheimer’s disease. Geriatr Psychol Neuropsychiatr Vieil 13(2):195–204
Henkin Y, Waldman A, Kihon-Rabin L (2007) The benefits of bilateral versus unilateral amplification for the elderly: are two always better than one? J Basic Clin Physiol Pharmacol 18:201–216
Hommet C, Beauchet O, Moroni C et al (2009) Cerebral lateralization and hemispheric interaction in aging: what about dichotic listening? Psychol NeuroPsychiatr Vieil 7(1):65–72
Kimura D (1961) Some effects of temporal-lobe damage on auditory perception. Can J Psychol 15:156–165
Hugdahl K (2003) Dichotic listening in the study of auditory laterality. In: Hugdahl K, Davidson RJ (eds) The asymmetrical brain. MIT Press, Cambridge, pp 441–475
Acknowledgments
I, Alexandre Villeneuve, as the corresponding author, certifies that I listed everyone who contributed significantly to this work. All patients gave their written consent for the use of these data and this study has been approved by the local ethics committee under the number 2014-A01708-39.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
All authors declare that they have no conflict of interest.
Ethical approval
All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee (registered under the number 2014-A01708-39) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent
Informed consent was obtained from all individual participants included in the study.
Rights and permissions
About this article
Cite this article
Villeneuve, A., Hommet, C., Aussedat, C. et al. Audiometric evaluation in patients with Alzheimer’s disease. Eur Arch Otorhinolaryngol 274, 151–157 (2017). https://doi.org/10.1007/s00405-016-4257-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00405-016-4257-1