Abstract
The first aim of this study was to evaluate the survival of the patients who underwent surgery due to lip squamous cell carcinoma (SCC). Furthermore, the predictive value of the prognostic factors regarding overall outcome was also assessed. The secondary objective was to justify the need of a prophylactic neck dissection according to the tumor size. One hundred and one cases with lip SCC were included in this study. The data regarding prognostic factors and survival were retrospectively collected. The 5-year survival rate was found to be 82.1 %. Among the multiple prognostic factors, only age and disease stage had significant impact on survival (p < 0.05). Lymph nodes were positive in two (3.0 %) T1, 3 (11.5 %) T2, one (16.6 %) T3 and 3 (100 %) T4 patients. In Turkish population, the 5-year survival rate was found to be 82.1 %. Age and disease stage were independent factors which have significant impact on survival. In geriatric population, the 5-year survival rate was 69.6 %. There was an increased prevalence of the disease among women in the geriatric population. We suggest elective neck dissection and aggressive treatment for T2 tumors especially if the patient has multiple risk factors such as high tumor thickness and poor prognostic indicators such as increased age.
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Rena W, Lia Y, Liua C et al (2014) Surgical management of squamous cell carcinoma of the lower lip: an experience of 109 cases. Med Oral Patol Oral Cir Bucal 19(4):398–402
Salgarelli AC, Sartorelli F, Cangiano A, Collini M (2005) Treatment of lower lip cancer: an experience of 48 cases. Int J Oral Maxillofac Surg 34:27–32
Chen J, Katz RV, Krutchkoff DJ, Eisenberg E (1992) Lip cancer. Incidence trends in Connecticut, 1935–1985. Cancer 70:2025–2030
Hoffman HT, Karnell LH, Funk GF, Robinson RA, Menck HR (1998) The National Cancer Data Base report on cancer of the head and neck. Arch Otolaryngol Head Neck Surg 124:951–962
Zitsch RP, Park CW, Renner GJ, Rea JL (1995) Outcome analysis for lip carcinoma. Otolaryngol Head Neck Surg 113:589–596
Hasson O (2008) Squamous cell carcinoma of the lower lip. J Oral Maxillofac Surg 66:1259–1262
de Visscher JG, Schaapveld M, Otter R, Visser O, van der Waal I (1998) Epidemiology of cancer of the lip in The Netherlands. Oral Oncol 34:421–426
Zitsch RP (1993) Carcinoma of the lip. Otolaryngol Clin North Am 26:265–277
Géraud C, Koenen W, Neumayr L et al (2012) Lip cancer: retrospective analysis of 181 cases. J Dtsch Dermatol Ges 10(2):121–127
Czerninski R, Zini A, Sgan-Cohen HD (2010) Lip cancer: incidence, trends, histology and survival: 1970–2006. Br J Dermatol 162(5):1103–1109
Thawley SE, Panje WR, Batsakis JG, Lindberg RD (1999) Comprehensive management of head and neck tumors. Saunders, Philadelphia, pp 673–685
Listl S, Jansen L, Stenzinger A et al (2013) Survival of patients with oral cavity cancer in Germany. PLoS One 8(1):53415
de Visscher JG, van den Elsaker K, Grond AJ, van der Wal JE, van der Waal I (1998) Surgical treatment of squamous cell carcinoma of the lower lip: evaluation of long-term results and prognostic factors–a retrospective analysis of 184 patients. J Oral Maxillofac Surg 56(7):814–820
Vukadinovic M, Jezdic Z, Petrovic M, Medenica LM, Lens M (2007) Surgical management of squamous cell carcinoma of the lip: analysis of a 10-year experience in 223 patients. J Oral Maxillofac Surg 65(4):675–679
Pinto FR, de Matos LL, Palermo FC et al (2014) Tumor thickness as an independent risk factor of early recurrence in oral cavity squamous cell carcinoma. Eur Arch Otorhinolaryngol 271(6):1747–1754
Onerci M, Yilmaz T, Gedikoglu G (2000) Tumor thickness as a predictor of cervical lymph node metastases in squamous cell carcinoma of the lower lip. Otolaryngol Head Neck Surg 122:139–142
Vanderlei JP, Pereira-Filho FJ, da Cruz FA et al (2013) Management of neck metastases in T2N0 lip squamous cell carcinoma. Am J Otolaryngol 34(2):103–106
Vartanian JG, Carvalho AL, Filho MJA et al (2004) Predictive factors and distribution of lymph node metastases in lip cancer patients and their implications on the treatment of the neck. Oral Oncol 40:223–227
Buccur A, Stefanescu L (2004) Management of patients with squamous cell carcinoma of the lower lip and N0-neck. J Craniomaxillofac Surg 32:16–18
Luna-Ortiz K, Güemes-Meza A, Villavicencio-Valencia V, Mosqueda-Taylor A (2004) Lip cancer experience in Mexico. An 11-year retrospective study. Oral Oncol 40(10):992–999
Harris L, Higgins K, Enepekides D (2012) Local flap reconstruction of acquired lip defects. Curr Opin Otolaryngol Head Neck Surg. 20(4):254–261
Amar A, Franzi SA, Curioni OA et al (2004) Esvaziamento cervical no tratamento do carcinoma epidermóide de lábio (Neck dissection in the treatment of epidermoid carcinoma of the lip). Rev Bras Otorrinolaringol 70:772–775
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Ozturk, K., Gode, S., Erdogan, U. et al. Squamous cell carcinoma of the lip: survival analysis with long-term follow-up. Eur Arch Otorhinolaryngol 272, 3545–3550 (2015). https://doi.org/10.1007/s00405-014-3415-6
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DOI: https://doi.org/10.1007/s00405-014-3415-6