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Unbalanced oxidative status in idiopathic sudden sensorineural hearing loss

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

An impaired cochlear perfusion seems to be an important etiopathogenetic event in idiopathic sudden sensorineural hearing loss (ISSNHL). Recently, oxidative stress has been proposed as risk factors of microvascular damage. This observational study aimed to evaluate the possible role of oxidative stress in ISSNHL. In thirty-nine ISSNHL patients and seventy healthy subjects serum reactive oxygen species concentrations (ROS) and total antioxidant capacity (TAC) were measured by spectrophotometric methods on F.R.E.E. analyzer (Diacron International, Italy). Moreover, a global oxidative stress index (Oxidative-INDEX), reflecting both oxidative and antioxidant counterparts, was also calculated. 25/39 patients showed oxidative stress due to ROS levels significantly higher than controls (348.2 ± 84.8 vs. 306.75 ± 46.7 UCarr; p = 0.001). The Oxidative-INDEX was significantly higher in patients than in controls (0.75 ± 2.4 vs. −0.0007 ± 1.28 AU, p = 0.03). As oxidative stress is a key determinant in endothelial dysfunction, our findings could suggest vascular impairment involvement in ISSNHL etiopathogenesis.

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Acknowledgments

The authors are very grateful to Mrs Mary Coduri for linguistic consultation.

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Authors and Affiliations

  1. Dipartimento di Scienze Specialistiche e Chirurgiche, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122, Milan, Italy

    Pasquale Capaccio, Lorenzo Pignataro, Lorenzo M. Gaini & Paolo E. Sigismund

  2. Dipartimento di Scienze Mediche, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

    Cristina Novembrino, Valentina Uva & Fabrizia Bamonti

  3. Fondazione F.lli Confalonieri, Dipartimento di Scienze Mediche, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

    Rachele De Giuseppe

  4. Dipartimento di Ematologia, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

    Armando Tripodi

Authors
  1. Pasquale Capaccio
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  2. Lorenzo Pignataro
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  3. Lorenzo M. Gaini
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  4. Paolo E. Sigismund
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  5. Cristina Novembrino
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  6. Rachele De Giuseppe
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  7. Valentina Uva
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  8. Armando Tripodi
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  9. Fabrizia Bamonti
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Correspondence to Paolo E. Sigismund.

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Capaccio, P., Pignataro, L., Gaini, L.M. et al. Unbalanced oxidative status in idiopathic sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol 269, 449–453 (2012). https://doi.org/10.1007/s00405-011-1671-2

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  • DOI: https://doi.org/10.1007/s00405-011-1671-2

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