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Intrauterine interventions options for preventing recurrence after hysteroscopic adhesiolysis: a systematic review and network meta-analysis of randomized controlled trials

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Abstract

Purpose

Recurrence of adhesions after hysteroscopic adhesiolysis is a challenging clinical problem without a unified management approach. Therefore, we conducted a network meta-analysis that considered both direct and indirect comparisons between interventions to identify optimal strategies for preventing recurrence.

Methods

We searched for research trials published up to July 2023 from PubMed, Embase and the Cochrane Database. We selected randomized controlled trials comparing the use of different interventions for the prevention of adhesion recurrence, with no language or regional restrictions. We used random-effects models to assess odds ratios (OR) and mean difference (MD) with 95% confidence intervals (CI). Adverse events associated with the interventions were also assessed. This study was registered on PROSPERO, CRD42023449068.

Results

Data from 21 randomized controlled trials involving 2406 patients were synthesized, including interventions with balloon, amnion, platelet-rich plasma (PRP), intrauterine device (IUD), hyaluronic acid (HA), platelet-rich fibrin (PRF), and granulocyte colony-stimulating factor (G-CSF). The top 5 interventions for change in AFS scores were: PRP + Balloon (MD = 5.44; 95% CI, 2.63–8.25), Amnion + Balloon (MD = 5.08; 95% CI, 2.71–7.44), IUD + Balloon (MD = 4.89; 95% CI, 2.49–7.30), HA + Balloon (MD = 3.80; 95% CI, 1.78–5.82), and G-CSF + Balloon (MD = 3.84; 95% CI, 1.05–6.63). There were no statistically significant differences between interventions in the recurrence rate of moderate-to-severe uterine adhesions and the clinical pregnancy rate. Most interventions were safe.

Conclusions

To our knowledge, this is the most comprehensive network meta-analysis to date of interventions for preventing postoperative intrauterine adhesion recurrence. Our results indicate that PRP + Balloon seems to be the most effective approach.

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Data availability

The data are derived from published studies.

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Funding

Funding provided by Shaanxi Provincial Health Commission (Grant number: 2021D022) and Second Affiliated Hospital of Harbin Medical University (Grant number: 2021LCYJ035).

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  1. Ruonan Tang and Wanlin Zhang contributed equally to this work.

Authors and Affiliations

  1. Xi’an Medical University, Xi’an, Shaanxi, China

    Ruonan Tang, Wenyi Li & Xinxin Chen

  2. Department of Gynecology and Obstetrics, Reproductive Medicine Center, Tangdu Hospital, Air Force Medical University, No. 1 Xinsi Road, Baqiao District, Xi’an, Shaanxi, China

    Ruonan Tang, Wanlin Zhang, Xifeng Xiao, Wenyi Li, Xinxin Chen & Xiaohong Wang

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Contributions

X. H. W. and R. N. T. conceived and designed the study. R. N. T., X.F.X. and W. L. Z. selected articles and extracted the data. R. N. T. and W. Y. L. analyzed the data. R. N. T., W. L. Z., and X. X. C. wrote the manuscript. X. H. W., X.F.X. and W.Y.L. contributed to the writing of final version of the manuscript. All authors agreed and reviewed the final version of the manuscript.

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Correspondence to Xiaohong Wang.

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Tang, R., Zhang, W., Xiao, X. et al. Intrauterine interventions options for preventing recurrence after hysteroscopic adhesiolysis: a systematic review and network meta-analysis of randomized controlled trials. Arch Gynecol Obstet 309, 1847–1861 (2024). https://doi.org/10.1007/s00404-024-07460-y

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