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Management of an incompetent mid-second (mid-2nd) trimester absent ecto-cervix: a case series. Cervical amplification pre-cerclage insertion

  • Maternal Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Background

Cervical cerclage is a treatment for an incompetent cervix, the latter being a contributor to spontaneous preterm birth. There is significant difficulty with a transvaginal cerclage insertion for the absent vaginal or ecto-cervix in the mid-2nd trimester period resulting in a higher risk of late miscarriages, extremely preterm labour with increased neonatal morbidity and mortality.

Methods

A retrospective review of 5 consecutive cases managed by a surgical technique—modified high vaginal cerclage insertion at 18-20 weeks—and adjunct protocols which included vaginal progesterone use, serial infection screening and lifestyle advice, over a 12-month period ending in August 2021, is presented. Inclusion criteria included minimal or absent ecto-cervix, singleton pregnancies with an incompetent cervix attending for a vaginal cerclage whilst exclusion criteria were the usual contraindications to a cerclage insertion. Primary outcome was delivery after 34 weeks whilst seconday outcomes included maternal hemorrhage, bowel/bladder injury, chorioamnionitis and neonatal admission.

Results

A increased gestational latency of 13 gestational weeks (range 12–18). Mean gestational age at delivery was 36 weeks +1 (253 days) with a range of 241–264 days. Delivery after 34 weeks gestational age was 100% with no maternal surgical complications and corresponding neonatal outcomes.

Conclusion

There is a potential therapeutic benefit of this technique and adjunct management, in managing an incompetent mid-2nd trimester absent ecto-cervix.

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Data availability

No.

References

  1. Alfirevic Z, Stampalija T, Medley N (2017) Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy. Cochrane Database Syst Rev 6:CD008991. https://doi.org/10.1002/14651858.CD008991.pub3

    Article  PubMed  Google Scholar 

  2. Owen J, Hankins G, Iams JD et al (2009) Multicenter randomized trial of cerclage for preterm birth prevention in high-risk women with shortened midtrimester cervical length. Am J Obstet Gynecol 201(4):375.e1-375.e8

    Article  Google Scholar 

  3. Shennan A, Story L, Jacobsson B, Grobman WA, The FIGO Working Group for Preterm Birth (2021) FIGO good practice recommendations on cervical cerclage for prevention of preterm birth. Int J Gynecol Obstet 155:19–22. https://doi.org/10.1002/ijgo.13835

    Article  Google Scholar 

  4. Namouz S, Porat S, Okun N, Windrim R, Farine D (2013) Emergency cerclage: literature review. Obstet Gynecol Surv 68(5):379–388. https://doi.org/10.1097/OGX.0b013e31828737c7

    Article  PubMed  Google Scholar 

  5. Wierzchowska-Opoka M, Kimber-Trojnar Ż, Leszczyńska-Gorzelak B (2021) Emergency cervical cerclage. J Clin Med 10(6):1270. https://doi.org/10.3390/jcm10061270

    Article  PubMed  PubMed Central  Google Scholar 

  6. Hezelgrave NL, Watson HA, Ridout A, Diab F, Seed PT, Chin-Smith E, Tribe RM, Shennan AH (2016) Rationale and design of SuPPoRT: a multicentre randomised controlled trial to compare three treatments: cervical cerclage, cervical pessary and vaginal progesterone, for the prevention of preterm birth in women who develop a short cervix. BMC Pregnancy Childbirth 16(1):358. https://doi.org/10.1186/s12884-016-1148-9

    Article  PubMed  PubMed Central  Google Scholar 

  7. National Institute for Health and Care Excellence (2018) IP overview: laparoscopic cerclage for cervical incompetence to prevent late miscarriage or preterm birth (NICE IP 379/2). Accessed Date 27th Dec 2021, https://www.nice.org.uk/guidance/ipg639/documents/overview-2.

  8. Moawad GN, Tyan P, Bracke T et al (2018) Systematic review of transabdominal cerclage placed via laparoscopy for the prevention of preterm birth. J Minim Invasive Gynecol 25:277–286

    Article  Google Scholar 

  9. Israfi-Bayli F, Toozs-Hobson P, Ismail K (2014) Cerclage outcome by the type of suture material (COTS): study protocol for a pilot and feasibility randomised controlled trial. Trials 15:415 https://doi.org/10.1186/1745-6215-15-415

    Article  Google Scholar 

  10. Cook JR, Chatfield S, Chandiramani M et al (2017) Cerclage position, cervical length and preterm delivery in women undergoing ultrasound indicated cervical cerclage: A retrospective cohort study. PLoS ONE 12(6):e0178072

    Article  Google Scholar 

  11. Rastogi S et al (2020) Tolerance of chlorhexidine gluconate vaginal cleansing solution: a randomized controlled trial. J Gyneco Surg 36(1):13–19

    Article  Google Scholar 

  12. Lakhi NA, Tricorico G, Osipova Y, Moretti ML (2019) Vaginal cleansing with chlorhexidine gluconate or povidone-iodine prior to cesarean delivery: a randomized comparator-controlled trial. Am J Obstet Gynecol MFM 1(1):2–9. https://doi.org/10.1016/j.ajogmf.2019.03.004

    Article  PubMed  Google Scholar 

  13. Baumer A, Gimovsky A, Gallagher M, Leftwich MC (2019) A synthetic cervix model and the impact of softness on cerclage integrity. Interface Focus 9(5):20190009. https://doi.org/10.1098/rsfs.2019.0009

    Article  PubMed  PubMed Central  Google Scholar 

  14. Nicolaides KH, Syngelaki A, Poon LC et al (2016) A randomized trial of a cervical pessary to prevent preterm singleton birth. N Engl J Med 374:1044–1052

    Article  CAS  Google Scholar 

  15. Dugoff L, Berghella V, Sehdev H, Mackeen AD, Goetzl L, Ludmir J (2018) Prevention of preterm birth with pessary in singletons (PoPPS): randomized controlled trial. Ultrasound Obstet Gynecol 51:573–579. https://doi.org/10.1002/uog.18908

    Article  CAS  PubMed  Google Scholar 

  16. Norman JE, Marlow N, Messow CM, OPPTIMUM study group et al (2016) Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial. Lancet 387:2106–2116

    Article  CAS  Google Scholar 

  17. Jarde A, Lutsiv O, Beyene J, McDonald SD (2018) Vaginal progesterone, oral progesterone, 17-OHPC, cerclage, and pessary for preventing preterm birth in at-risk singleton pregnancies: an updated systematic review and network meta-analysis. BJOG. https://doi.org/10.1111/1471-0528.15566

    Article  PubMed  Google Scholar 

  18. EPPPIC Group (2021) Evaluating Progestogens for Preventing Preterm birth International Collaborative (EPPPIC): meta-analysis of individual participant data from randomised controlled trials. Lancet 397:1183–1194. https://doi.org/10.1016/S0140-6736(21)00217-8

    Article  Google Scholar 

  19. Enakpene CA, DiGiovanni L, Jones TN, Marshalla M, Mastrogiannis D, Della TM (2018) Cervical cerclage for singleton pregnant patients on vaginal progesterone with progressive cervical shortening. Am J Obstet Gynecol 219(4):397.e1-397.e10. https://doi.org/10.1016/j.ajog.2018.06.020 (Epub 2018 Jul 11 PMID: 30017683)

    Article  CAS  Google Scholar 

  20. Lavie M, Shamir-Kaholi N, Lavie I et al (2020) Outcomes of ultrasound and physical-exam based cerclage: assessment of risk factors and the role of adjunctive progesterone in preventing preterm birth—a retrospective cohort study. Arch Gynecol Obstet 301:981–986. https://doi.org/10.1007/s00404-020-05482-w

    Article  CAS  PubMed  Google Scholar 

  21. Sosa CG, Althabe F, Belizán JM, Bergel E (2015) Bed rest in singleton pregnancies for preventing preterm birth. Cochrane Database Syst Rev 3:CD003581. https://doi.org/10.1002/14651858.CD003581.pub3 (PMID: 25821121; PMCID: PMC7144825)

    Article  Google Scholar 

  22. Critchfield AS, Yao G, Jaishankar A, Friedlander RS, Lieleg O et al (2013) Cervical mucus properties stratify risk for preterm birth. PLoS ONE 8(8):e69528. https://doi.org/10.1371/journal.pone.0069528

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Son M, Miller ES (2017) Predicting preterm birth: cervical length and fetal fibronectin. Semin Perinatol 41(8):445–451. https://doi.org/10.1053/j.semperi.2017.08.002

    Article  PubMed  PubMed Central  Google Scholar 

  24. Goldenburg RL, Mercer BM, Meis PJ, Copper RL, Das A, McNellis D (1996) The preterm prediction study: fetal fibronectin testing and spontaneous preterm birth. NICHD Maternal Fetal Medicine Units Network. Obstet Gynecol 87(5 Pt 1):643–648

    Article  Google Scholar 

  25. Krispin E, Danieli-Gruber S, Hadar E et al (2019) Primary, secondary, and tertiary preventions of preterm birth with cervical cerclage. Arch Gynecol Obstet 300:305–312. https://doi.org/10.1007/s00404-019-05184-y

    Article  PubMed  Google Scholar 

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The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

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Contributions

TOA—Study design, Data collection and Manuscript writing. AAA—manuscript writing. UOC—manuscript writing.

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Correspondence to T. O. Adedipe.

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Informed consent was obtained from all individual participants included in the study.

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Adedipe, T.O., Akintunde, A.A. & Chukwujama, U.O. Management of an incompetent mid-second (mid-2nd) trimester absent ecto-cervix: a case series. Cervical amplification pre-cerclage insertion. Arch Gynecol Obstet 306, 969–975 (2022). https://doi.org/10.1007/s00404-022-06694-y

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