Abstract
Background
Cervical cerclage is a treatment for an incompetent cervix, the latter being a contributor to spontaneous preterm birth. There is significant difficulty with a transvaginal cerclage insertion for the absent vaginal or ecto-cervix in the mid-2nd trimester period resulting in a higher risk of late miscarriages, extremely preterm labour with increased neonatal morbidity and mortality.
Methods
A retrospective review of 5 consecutive cases managed by a surgical technique—modified high vaginal cerclage insertion at 18-20 weeks—and adjunct protocols which included vaginal progesterone use, serial infection screening and lifestyle advice, over a 12-month period ending in August 2021, is presented. Inclusion criteria included minimal or absent ecto-cervix, singleton pregnancies with an incompetent cervix attending for a vaginal cerclage whilst exclusion criteria were the usual contraindications to a cerclage insertion. Primary outcome was delivery after 34 weeks whilst seconday outcomes included maternal hemorrhage, bowel/bladder injury, chorioamnionitis and neonatal admission.
Results
A increased gestational latency of 13 gestational weeks (range 12–18). Mean gestational age at delivery was 36 weeks +1 (253 days) with a range of 241–264 days. Delivery after 34 weeks gestational age was 100% with no maternal surgical complications and corresponding neonatal outcomes.
Conclusion
There is a potential therapeutic benefit of this technique and adjunct management, in managing an incompetent mid-2nd trimester absent ecto-cervix.
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References
Alfirevic Z, Stampalija T, Medley N (2017) Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy. Cochrane Database Syst Rev 6:CD008991. https://doi.org/10.1002/14651858.CD008991.pub3
Owen J, Hankins G, Iams JD et al (2009) Multicenter randomized trial of cerclage for preterm birth prevention in high-risk women with shortened midtrimester cervical length. Am J Obstet Gynecol 201(4):375.e1-375.e8
Shennan A, Story L, Jacobsson B, Grobman WA, The FIGO Working Group for Preterm Birth (2021) FIGO good practice recommendations on cervical cerclage for prevention of preterm birth. Int J Gynecol Obstet 155:19–22. https://doi.org/10.1002/ijgo.13835
Namouz S, Porat S, Okun N, Windrim R, Farine D (2013) Emergency cerclage: literature review. Obstet Gynecol Surv 68(5):379–388. https://doi.org/10.1097/OGX.0b013e31828737c7
Wierzchowska-Opoka M, Kimber-Trojnar Ż, Leszczyńska-Gorzelak B (2021) Emergency cervical cerclage. J Clin Med 10(6):1270. https://doi.org/10.3390/jcm10061270
Hezelgrave NL, Watson HA, Ridout A, Diab F, Seed PT, Chin-Smith E, Tribe RM, Shennan AH (2016) Rationale and design of SuPPoRT: a multicentre randomised controlled trial to compare three treatments: cervical cerclage, cervical pessary and vaginal progesterone, for the prevention of preterm birth in women who develop a short cervix. BMC Pregnancy Childbirth 16(1):358. https://doi.org/10.1186/s12884-016-1148-9
National Institute for Health and Care Excellence (2018) IP overview: laparoscopic cerclage for cervical incompetence to prevent late miscarriage or preterm birth (NICE IP 379/2). Accessed Date 27th Dec 2021, https://www.nice.org.uk/guidance/ipg639/documents/overview-2.
Moawad GN, Tyan P, Bracke T et al (2018) Systematic review of transabdominal cerclage placed via laparoscopy for the prevention of preterm birth. J Minim Invasive Gynecol 25:277–286
Israfi-Bayli F, Toozs-Hobson P, Ismail K (2014) Cerclage outcome by the type of suture material (COTS): study protocol for a pilot and feasibility randomised controlled trial. Trials 15:415 https://doi.org/10.1186/1745-6215-15-415
Cook JR, Chatfield S, Chandiramani M et al (2017) Cerclage position, cervical length and preterm delivery in women undergoing ultrasound indicated cervical cerclage: A retrospective cohort study. PLoS ONE 12(6):e0178072
Rastogi S et al (2020) Tolerance of chlorhexidine gluconate vaginal cleansing solution: a randomized controlled trial. J Gyneco Surg 36(1):13–19
Lakhi NA, Tricorico G, Osipova Y, Moretti ML (2019) Vaginal cleansing with chlorhexidine gluconate or povidone-iodine prior to cesarean delivery: a randomized comparator-controlled trial. Am J Obstet Gynecol MFM 1(1):2–9. https://doi.org/10.1016/j.ajogmf.2019.03.004
Baumer A, Gimovsky A, Gallagher M, Leftwich MC (2019) A synthetic cervix model and the impact of softness on cerclage integrity. Interface Focus 9(5):20190009. https://doi.org/10.1098/rsfs.2019.0009
Nicolaides KH, Syngelaki A, Poon LC et al (2016) A randomized trial of a cervical pessary to prevent preterm singleton birth. N Engl J Med 374:1044–1052
Dugoff L, Berghella V, Sehdev H, Mackeen AD, Goetzl L, Ludmir J (2018) Prevention of preterm birth with pessary in singletons (PoPPS): randomized controlled trial. Ultrasound Obstet Gynecol 51:573–579. https://doi.org/10.1002/uog.18908
Norman JE, Marlow N, Messow CM, OPPTIMUM study group et al (2016) Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial. Lancet 387:2106–2116
Jarde A, Lutsiv O, Beyene J, McDonald SD (2018) Vaginal progesterone, oral progesterone, 17-OHPC, cerclage, and pessary for preventing preterm birth in at-risk singleton pregnancies: an updated systematic review and network meta-analysis. BJOG. https://doi.org/10.1111/1471-0528.15566
EPPPIC Group (2021) Evaluating Progestogens for Preventing Preterm birth International Collaborative (EPPPIC): meta-analysis of individual participant data from randomised controlled trials. Lancet 397:1183–1194. https://doi.org/10.1016/S0140-6736(21)00217-8
Enakpene CA, DiGiovanni L, Jones TN, Marshalla M, Mastrogiannis D, Della TM (2018) Cervical cerclage for singleton pregnant patients on vaginal progesterone with progressive cervical shortening. Am J Obstet Gynecol 219(4):397.e1-397.e10. https://doi.org/10.1016/j.ajog.2018.06.020 (Epub 2018 Jul 11 PMID: 30017683)
Lavie M, Shamir-Kaholi N, Lavie I et al (2020) Outcomes of ultrasound and physical-exam based cerclage: assessment of risk factors and the role of adjunctive progesterone in preventing preterm birth—a retrospective cohort study. Arch Gynecol Obstet 301:981–986. https://doi.org/10.1007/s00404-020-05482-w
Sosa CG, Althabe F, Belizán JM, Bergel E (2015) Bed rest in singleton pregnancies for preventing preterm birth. Cochrane Database Syst Rev 3:CD003581. https://doi.org/10.1002/14651858.CD003581.pub3 (PMID: 25821121; PMCID: PMC7144825)
Critchfield AS, Yao G, Jaishankar A, Friedlander RS, Lieleg O et al (2013) Cervical mucus properties stratify risk for preterm birth. PLoS ONE 8(8):e69528. https://doi.org/10.1371/journal.pone.0069528
Son M, Miller ES (2017) Predicting preterm birth: cervical length and fetal fibronectin. Semin Perinatol 41(8):445–451. https://doi.org/10.1053/j.semperi.2017.08.002
Goldenburg RL, Mercer BM, Meis PJ, Copper RL, Das A, McNellis D (1996) The preterm prediction study: fetal fibronectin testing and spontaneous preterm birth. NICHD Maternal Fetal Medicine Units Network. Obstet Gynecol 87(5 Pt 1):643–648
Krispin E, Danieli-Gruber S, Hadar E et al (2019) Primary, secondary, and tertiary preventions of preterm birth with cervical cerclage. Arch Gynecol Obstet 300:305–312. https://doi.org/10.1007/s00404-019-05184-y
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TOA—Study design, Data collection and Manuscript writing. AAA—manuscript writing. UOC—manuscript writing.
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Adedipe, T.O., Akintunde, A.A. & Chukwujama, U.O. Management of an incompetent mid-second (mid-2nd) trimester absent ecto-cervix: a case series. Cervical amplification pre-cerclage insertion. Arch Gynecol Obstet 306, 969–975 (2022). https://doi.org/10.1007/s00404-022-06694-y
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DOI: https://doi.org/10.1007/s00404-022-06694-y