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Comparison of the Cook vaginal cervical ripening balloon with prostaglandin E2 insert for induction of labor in late pregnancy

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To compare the effectiveness of the Cook vaginal cervical ripening balloon (CCRB) with prostaglandin E2 (PGE2) insert for induction of labor in late pregnancy in primipara.

Methods

We evaluated the effectiveness and safety of induction of labor using the improved Bishop score after CCRB or PGE2 administration, total stage of labor, hours until delivery (hours from placement of CCRB or PGE2 insert to parturition and delivery), delivery rate within 24 h, spontaneous delivery rate, successful induction rate, overstimulation syndrome, urgent delivery rate, pain scores, cesarean section rate, and outcomes related to delivery and perinatal morbidity, such as puerperal infection rate, total cost, satisfaction survey, and so on.

Results

The improved Bishop Score and delivery rate within 24 h in the CCRB group were significantly higher than in the PGE2 group. The total stage of labor and hours until delivery in the CCRB group were significantly shorter than that in the PGE2 group. Rate of overstimulation syndrome and pain scores in the CCRB group were significantly lower than in the PGE2 group. Compared with the PGE2 group, the mean duration of hospitalization in the CCRB group was shorter and the total cost was less. No difference in satisfaction between the PGE2 and CCRB groups was observed.

Conclusions

Compared with PGE2, CCRB reduced the total stage of labor, hours until delivery, pain scores, mean length of hospitalization, and total cost. CCRB increased the rate of delivery within 24 h with similar safety and maternal satisfaction compared with PGE2.

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Funding

This study was supported by the grants from Science and Technology Benefit People Special of Qingdao Science and Technology Bureau in China (Grant number: 19-6-1-56-nsh).

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Qingdao Municipal Hospital, Qingdao, China

    Lijing Wang, Li Guo, Haiyan Hu, Yuanmei Li & Qian Zhang

  2. Medical Department, Qingdao Municipal Hospital, Qingdao, China

    Guanjun Wang

  3. Department of Obstetrics and Gynecology, Qingdao Women and Children’s Hospital, Qingdao, China

    Wenhong Cao

Authors
  1. Lijing Wang
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  2. Guanjun Wang
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  3. Wenhong Cao
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  4. Li Guo
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  5. Haiyan Hu
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  6. Yuanmei Li
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  7. Qian Zhang
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Contributions

LW designed the protocol and wrote the manuscript. GW, WC, and LG were responsible for statistics of experimental data. YL and HH were charge of chart making. QZ, as the corresponding author, designed the protocol and revised the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Qian Zhang.

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Conflict of interest

We have no conflicts of interest to declare.

Ethical approval

This study was approved by the institutional review board of Qingdao Municipal Hospital.

Informed consent

Informed consent was signed by all pregnant women involved.

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Wang, L., Wang, G., Cao, W. et al. Comparison of the Cook vaginal cervical ripening balloon with prostaglandin E2 insert for induction of labor in late pregnancy. Arch Gynecol Obstet 302, 579–584 (2020). https://doi.org/10.1007/s00404-020-05597-0

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  • DOI: https://doi.org/10.1007/s00404-020-05597-0

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