Skip to main content
Log in

Safety considerations regarding Methotrexate off-label use in tubal ectopic pregnancy

  • Correspondence
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

A Correction to this article was published on 26 August 2019

This article has been updated

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Change history

  • 26 August 2019

    In the original article publication, the authors given name and family name were interchanged.

References

  1. Brunello J, Guerby P, Cartoux C, Yazigi A, Baujat M, Parant O et al (2019) Can early βhCG change and baseline progesterone level predict treatment outcome in patients receiving single dose Methotrexate protocol for tubal ectopic pregnancy? Arch Gynecol Obstet 299(3):741–745

    Article  CAS  Google Scholar 

  2. Hajenius PJ, Engelsbel S, Mol BJW, Van der Veen F, Ankum WM, Bossuyt PMM et al (1997) Randomised trial of systemic methotrexate versus laparoscopic salpingostomy in tubal pregnancy. Lancet 350:774–779

    Article  CAS  Google Scholar 

  3. Stovall TG, Ling FW (1993) Single-dose methotrexate: an expanded clinical trial. Am J Obstet Gynecol 168:1759–1765

    Article  CAS  Google Scholar 

  4. Corsan GH, Karacan M, Qasim S, Bohrer MK, Ransom MX, Kemmann E (1995) Identification of hormonal parameters for successful systemic single-dose methotrexate therapy in ectopic pregnancy. Hum Reprod 10:2719–2722

    Article  CAS  Google Scholar 

  5. Barnhart K, Coutifaris C, Esposito M (2001) The pharmacology of methotrexate. Expert Opin Pharmacother. 2(3):409–417

    Article  CAS  Google Scholar 

  6. Committee on Practice Bulletin-Gynecology (2018) ACOG practice bulletin No. 191: tubal ectopic pregnancy. Obstet Gynecol 131(2):e65–e77

    Article  Google Scholar 

  7. Marret H, Fauconnier A, Dubernard G, Misme H, Lagarce L, Lesavre M et al (2016) Overview and guidelines of off-label use of methotrexate in ectopic pregnancy: report by CNGOF. Eur J Obstet Gynecol Reprod Biol. 205:105–109

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Fabien Vidal.

Ethics declarations

Conflict of interest

The authors declare no conflicts of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Brunello, J., Guerby, P., Cartoux, C. et al. Safety considerations regarding Methotrexate off-label use in tubal ectopic pregnancy. Arch Gynecol Obstet 300, 1095–1096 (2019). https://doi.org/10.1007/s00404-019-05254-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-019-05254-1

Navigation