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Efficacy of dienogest in improving pain in women with endometriosis: a 12-month single-center experience

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Abstract

Purpose

Dienogest has recently been marketed as a medical treatment for endometriosis. Given the recent introduction on the market of Dienogest, little data are available regarding its effectiveness in routine clinical practice.

Methods

The study is an observational, single-center, cohort study. Eligible was women with a surgical diagnosis of endometriosis dating back <24 months or a clinical/instrumental diagnosis of endometriosis and endometriosis-associated pelvic pain score of at least 40 mm on a 100-mm visual analog scale (VAS) at start of treatment and who had been taking Dienogest 2 mg once daily treatment at the time of study entry for no more than 30 days, consecutively observed between September 2013 to September 2014. In accordance with routine practice, women came back for clinical assessment and evaluation of pain after 1 (V1), 3 (V2), and 12 (V3) months.

Results

A total of 132 women were enrolled in the study. A total of 21 of the enrolled patients were released from the study during follow-up due to adverse effects. The mean pelvic pain VAS score at baseline was 8.9 (SD 1.3). The corresponding values were 6.7 (SD 3.2) and 5.7 (SD 3.7) for dyspareunia and dyschezia. The mean VAS scores progressively and significantly decreased to 0.9 (SD 1.6) for pelvic pain, 1.4 (SD 2.1) for dyspareunia and 0.2 (SD 0.9) for dyschezia, respectively, 12 months after start of treatment.

Conclusion

This study confirms that in routine clinical practice, Dienogest 2 mg is an effective and well-tolerated treatment for endometriosis-related pain in women with endometriosis.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, A.R.N.A.S. Civico Hospital, Piazza Nicola Leotta 4, 90127, Palermo, Italy

    A. Maiorana, Domenico Incandela, W. Alio, A. Mercurio, L. Giambanco & L. Alio

  2. Dipartimento Materno Infantile Clinica Ostetrico Ginecologica, Università di Milano, Fondazione IRCCS Ca’ Grande Ospedale Maggiore Policlinico, Via Commenda 12, 20122, Milan, Italy

    F. Parazzini

  3. Dipartimento di Scienze Cliniche e di Comunità, Universita’ di Milano, Via Commenda 9/12, 20122, Milan, Italy

    F. Parazzini

Authors
  1. A. Maiorana
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  2. Domenico Incandela
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  3. F. Parazzini
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  4. W. Alio
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  5. A. Mercurio
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  6. L. Giambanco
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  7. L. Alio
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Contributions

AM: project development. DI: data collection or management and manuscript writing/editing. FP: data analysis. WA: manuscript writing/editing. AM: manuscript writing/editing. LG: manuscript writing/editing. LA: project development.

Corresponding author

Correspondence to Domenico Incandela.

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Conflict of interest

FP received fee by Bayer SpA for participation to Editorial Board. The other authors declare that they are no conflict of interest. All authors have full control of all primary data and that they agree to allow the Journal to review their data if requested.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Maiorana, A., Incandela, D., Parazzini, F. et al. Efficacy of dienogest in improving pain in women with endometriosis: a 12-month single-center experience. Arch Gynecol Obstet 296, 429–433 (2017). https://doi.org/10.1007/s00404-017-4442-5

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  • DOI: https://doi.org/10.1007/s00404-017-4442-5

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