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Are progranulin levels associated with polycystic ovary syndrome and its possible metabolic effects in adolescents and young women?

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

Polycystic ovary syndrome (PCOS) is an important disease that may alter metabolic balances of the whole body. Progranulin is a growth factor which is related to epithelial, neuronal growth and oogenesis. Here, we aimed to investigate the diagnostic value of the levels of Progranulin in the clinical setting of PCOS, and its metabolic effects.

Methods

Forty-one adolescents and young women with PCOS and 39 age and body mass index matched adolescents and young women as a control group who attended to the youth center of a tertiary referral center were included in this cross-sectional case–control study. Progranulin levels, indices of insulin sensitivity, lipidemic markers, metabolic syndrome (MetS) criteria were compared between the groups.

Results

Progranulin levels in patients with PCOS (7.48 ± 1.93 ng/mL) were significantly higher than in the control group (6.25 ± 1.98 ng/mL) (p = 0.006). Luteinizing hormone (LH) levels, LH/Follicle stimulating hormone (FSH) ratios, free testosterone, dehydroepiandrosterone sulfate (DHEAS), C-reactive protein (CRP) levels in patients with PCOS were significantly higher than in the control group (p < 0.05, for all). The MetS was present in 8 (19.5 %) of the patients in the study group and in 1 (2.3 %) of the patients in the control group (p = 0.029). There was significant inverse correlation between high-density lipoprotein cholesterol (HDL-C) and progranulin levels of patients diagnosed with PCOS (p = 0.008).

Conclusions

Progranulin may be a novel biomarker for cardiovascular risk in patients with PCOS, thus these cases should be directed to close follow-up for possible cardiovascular diseases. Future larger studies should focus on this entity.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Zekai Tahir Burak Women’s Healthcare Training and Research Hospital, Talatpasa Bulvari, Hamamonu, Ankara, 06230, Turkey

    Ali Ozgur Ersoy, Aytekin Tokmak, Sibel Ozler, Efser Oztas, Ebru Ersoy & Nafiye Yilmaz

  2. Department of Biochemistry, Turgut Ozal University, Ankara, Turkey

    Huseyin Tugrul Celik & Husamettin Erdamar

Authors
  1. Ali Ozgur Ersoy
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  2. Aytekin Tokmak
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  3. Sibel Ozler
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  6. Huseyin Tugrul Celik
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  7. Husamettin Erdamar
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  8. Nafiye Yilmaz
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Correspondence to Ali Ozgur Ersoy.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Ersoy, A.O., Tokmak, A., Ozler, S. et al. Are progranulin levels associated with polycystic ovary syndrome and its possible metabolic effects in adolescents and young women?. Arch Gynecol Obstet 294, 403–409 (2016). https://doi.org/10.1007/s00404-016-4096-8

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  • DOI: https://doi.org/10.1007/s00404-016-4096-8

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