Abstract
Purpose
This study is to assess whether transient intrauterine fluid accumulation (IUFA) first noted during controlled ovarian hyperstimulation that does not persist on the day of embryo transfer not due to any identifiable pelvic pathology has any detrimental effect on in vitro fertilization (IVF) outcome.
Methods
From a database of 16,900 cycles, 144 patients with transient “physiological” IUFA were recruited. Four hundred fifty-one consecutive patients who had male factor infertility served as the control group. The amount of IUFA classified as largest dimension in the antero-posterior (AP) plane; ≤2, 3–5 or >5 mm.
Results
The mean female age, the mean number of embryos transferred and endometrial thickness on the day of hCG administration were comparable among the study and control groups. Similarly, clinical pregnancy, ongoing pregnancy and implantation rates were comparable among the study and control groups. Female age was noted to be the only significant independent predictor of ongoing pregnancy. The AP dimension of IUFA did not have any impact on pregnancy and implantation rates.
Conclusions
Transient IUFA not due to hydrosalpinx or any identifiable pelvic pathology has no detrimental effect on IVF pregnancy rates. Hence, cycle cancellation should be avoided in such cycles.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Akman MA, Erden HF, Bahçeci M (2005) Endometrial fluid visualized through ultrasonography during ovarian stimulation in IVF cycles impairs the outcome in tubal factor, but not PCOS, patients. Hum Reprod 20:906–909
Sharara FI, Prough SG (1999) Endometrial fluid collection in women with PCOS undergoing ovarian stimulation for IVF: a report of four cases. J Reprod Med 44:299–302
Drbohlav P, Halkova E, Masata J, Rezacova J, Cerny V, Rossova D (1998) The effect of endometrial infection on embryo implantation in the IVF and ET program. Ceska Gynekol 63:181–185
Lee RK, Yu SL, Chih YF, Tsai YC, Lin MH, Hwu YM, Huang WY, Su JT (2006) Effect of endometrial cavity fluid on clinical pregnancy rate in tubal embryo transfer. J Assist Reprod Genet 23:229–234
Katz E, Akman MA, Damewood MD, Garcia JE (1996) Deleterious effect of the presence of hydrosalpinx on implantation and pregnancy rates with in vitro fertilization. Fertil Steril 66:122–125
Andersen AN, Lindhard A, Loft A, Ziebe S, Andersen CY (1996) The infertile patient with hydrosalpinges—IVF with or without salpingectomy? Hum Reprod 11:2081–2084
Camus E, Poncelet C, Goffinet F, Wainer B, Merlet F, Nisand I, Philippe HJ (1999) Pregnancy rates after in vitro fertilization in cases of tubal infertility with and without hydrosalpinx: a meta-analysis of published comparative studies. Hum Reprod 14:1243–1249
Strandell A, Lindhard A (2002) Why does hydrosalpinx reduce fertility? The importance of hydrosalpinx fluid. Hum Reprod 17:1141–1145
He RH, Gao HJ, Li YQ, Zhu XM (2010) The associated factors to endometrial cavity fluid and the relevant impact on the IVF-ET outcome. Reprod Biol Endocrinol 8:46
Chien LW, Au HK, Xiao J, Tzeng CR (2002) Fluid accumulation within the uterine cavity reduces pregnancy rates in women undergoing IVF. Hum Reprod 17:351–356
Levi AJ, Segars JH, Miller BT, Leondires MP (2001) Endometrial cavity fluid is associated with poor ovarian response and increased cancellation rates in ART cycles. Hum Reprod 16:2610–2615
Conflict of interest
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Polat, M., Boynukalin, F.K., Yarali, İ. et al. Transient intrauterine fluid accumulation not due to hydrosalpinx or any identifiable pelvic pathology is not detrimental to IVF outcome. Arch Gynecol Obstet 290, 569–573 (2014). https://doi.org/10.1007/s00404-014-3245-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00404-014-3245-1