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Placental pathologies associated with intra-uterine fetal growth restriction complicated with and without oligohydramnios

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Abstract

Purpose

To compare the placental pathologies and perinatal outcomes in fetal growth restriction (FGR) pregnancies with and without oligohydramnios.

Methods

A retrospective cohort study, comparing placental findings in all singleton deliveries with FGR.

Results

Macroscopic placental findings were available for 1,104 singleton FGR pregnancies. A total of 397 placentas were microscopically examined; of which 89 placentas were of FGR neonates who had oligohydramnios. No significant differences in placental vascular mal-perfusion were found between pregnancies with and without oligohydramnios (69.3 vs. 74.3%; P = 0.357). Likewise, no significant differences were noted between the groups regarding diffuse villous fibrosis (10.1 vs. 4.9%; P = 0.573), and amnion cell metaplasia (65.9 vs. 64.3%; P = 0.779). Cases of FGR complicated with oligohydramnios had significantly higher rates of perinatal mortality (9.9 vs. 5.9%; P = 0.028), preterm deliveries (34.9 ± 3.4 vs. 35.4 ± 3.1 weeks of pregnancy; P = 0.041), and lower birth weight (1,737 ± 542 vs. 1,845 ± 467 g; P = 0.002) compared to FGR without oligohydramnios.

Conclusions

Oligohydramnios is a significant risk factor for adverse perinatal outcome in FGR pregnancies; nevertheless, no significant differences in placental pathologies were noted.

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Conflict of interest statement

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Authors and Affiliations

  1. Department of Pathology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beersheba, Israel

    Liat Apel-Sarid

  2. Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beersheba, Israel

    Amalia Levy

  3. Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, P.O. Box 151, Beersheba, Israel

    Gershon Holcberg & Eyal Sheiner

Authors
  1. Liat Apel-Sarid
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  2. Amalia Levy
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  3. Gershon Holcberg
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  4. Eyal Sheiner
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Corresponding author

Correspondence to Eyal Sheiner.

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Apel-Sarid, L., Levy, A., Holcberg, G. et al. Placental pathologies associated with intra-uterine fetal growth restriction complicated with and without oligohydramnios. Arch Gynecol Obstet 280, 549–552 (2009). https://doi.org/10.1007/s00404-009-0937-z

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  • DOI: https://doi.org/10.1007/s00404-009-0937-z

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