Abstract
Background
A liposarcoma is the most frequent soft tissue sarcoma found in adults, however, a liposarcoma arising in uterus is extremely rare. Indeed, a liposarcoma coexistent with a leiomyoma is even rarer and there is only one case has been reported in the English literature to date.
Case
We describe a case of the uterine liposarcoma arising in a leiomyoma in 48-year-old woman who presented with dysmenorrhea, brownish vaginal discharge, and a rapidly enlarging lower abdominal mass. The tumor emerged from the lower segment of the endometrium and filled the endometrial cavity as a polypoid lesion. The authors of this study documented the adipocyte origin of the tumor with immunohistochemical and electron microscopical studies, the available literature was reviewed and the possible histogenesis was discussed.
Conclusion
We herein report a case of very rare primary liposarcoma arising in a submucosal uterine leiomyoma.
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References
Fadare O (2006) Common sarcomas of the uterine cervix: a review of selected entities. Diagn Pathol 1:30–35
Karateke A, Gurbuz A, Kabaca C, Alkan A, Kir G, Centiner H (2005) Uterine liposarcoma in a young woman: a case report. Int J Gynecol Cancer 15:1230–1234
Levine PH, Wei XJ, Gagner JP, Flax H, Mittal K, Blank SV (2003) Pleomorphic liposarcoma of the uterus: case report and literature review. Int J Gynecol Pathol 22:407–411
Takeuchi K, Murata K, Funaki K, Fujita K, Hayakawa Y, Kitazawa S (2000) Liposarcoma of the uterine cervix: case report. Eur J Gynaecol Oncol 21:290–291
Bapat K, Brustein S (1989) Uterine sarcoma with liposarcomatous differentiation:report of a case and review of the literature. Int J Gynaecol Obstet 28:71–75
Obafunwa JO, Uguru VE (1990) Liposarcoma of the cervix. Trop Geogr Med 42:90–91
Veliath AJ, Hannah P, Ratnakar C, Jayanthi K, Aurora AL (1978) Primary liposarcoma of the cervix: a case report. Int J Gynaecol Obstet 16:75–79
Schneebauer J, Brinninger G, Halabi M, Nagi F (1996) Liposarcoma of the uterus. Gynakol Geburtshilfliche Rundsch 36:90–91
Chu PG, Arber DA, Weiss LM, Chang KL (2001) Utility of CD10 in distinguishing between endometrial stromal sarcoma and uterine smooth muscle tumors:an immunohistochemical comparison of 34 cases. Mod Pathol 14:465–471
Brandfass RT, Everts-Suarez EA (1955) Lipomatous tumors of the uterus: a review of the world’s literature with report of a case of true lipoma. Am J Obstet Gynecol 70:359–367
Pounder DJ (1982) Fatty tomours of the uterus. J Clin Pathol 35:1380–1383
Shintaku M (1997) Lipoleiomyomatous tomours of the uterus: a heterogeneous group, Histopathological study of five cases. Pathol Int 46:498–502
Enzinger FM, Weiss SW (2001) Soft tissue tumors, 4th edn. Mosby, St Louis, pp 670–687
Moinfar F, Azodi M, Tavassoli FA (2007) Uterine sarcoma. Pathology 39:55–71
Mittal K, Popiolek D, Demopoulos RI (2000) Uterine myxoid leiomyosarcoma within a leiomyoma. Hum Pathol 31:398–400
Stojsic Z, Bacetic D, Radevic B, Vasiljevic JD (2004) A well-differentiated liposarcoma co-existent with leiomyoma. Vojnosanit Pregl 61:565–568
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Hong, R., Lim, SC. & Jung, H. A myxoid liposarcoma arising in a leiomyoma of the uterus: a case report. Arch Gynecol Obstet 277, 445–448 (2008). https://doi.org/10.1007/s00404-007-0486-2
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DOI: https://doi.org/10.1007/s00404-007-0486-2