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Epoprostenol up-regulates serum adiponectin level in patients with systemic sclerosis: therapeutic implications

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Abstract

Introduction

Adiponectin, resistin and leptin belong to adipokines, a group of molecules secreted mainly by the adipose tissue, which impaired expression may be a missing link between various manifestations of systemic sclerosis. Adiponectin, which is also released in small amounts by the endothelium, possesses anti-inflammatory, anti-fibrotic and protective against endothelial injury properties. Both leptin and resistin exhibit features which are contradictory to adiponectin, as they trigger inflammation and the activation of skin fibroblasts. Epoprostenol is a prostaglandin analogue with powerful vasodilator activity and inhibitory effect on platelet aggregation. The aim of the study was to evaluate whether epoprostenol may have an effect on serum adipokine levels in patients with systemic sclerosis.

Methods

A total of 27 patients were included in the study and received epoprostenol intravenously (25 µg of per day for 3 consecutive days). Serum concentrations of total adiponectin, resistin and leptin were assessed with enzyme-linked immunosorbent essay (R&D Systems, Minneapolis, MN, USA).

Results

In all SSc patients, the basal level of adiponectin was significantly lower compared to healthy controls (mean 6.00 \(\pm \) 2.81 μg/ml vs. 8.8 \(\pm \) 4.3 μg/ml, p = 0.02) and basal level of resistin (mean 11.12 \(\pm \) 3.36 ng/ml vs. 8.54 \(\pm \) 3.07 ng/ml p = 0.02) was significantly higher than in the control group. The serum concentration of adiponectin increased significantly after treatment with epoprostenol (6.00 \(\pm \) 2.81 μg/ml vs 9.29 \(\pm \) 6.05 μg/ml; P = 0.002). The level of resistin and leptin remained unchanged.

Conclusion

Epoprostenol infusions up-regulate the serum concentration of adiponectin in patients with systemic sclerosis. In our opinion, future studies on treatments in systemic sclerosis should address the issue of their effect on adipokine metabolism.

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Acknowledgements

This research was carried out thanks to the financial support from Medical University of Warsaw, Poland (1M4/N/19/19).

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This study was funded by Medical University of Warsaw, Poland (1M4/N/19/19).

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  1. Department of Dermatology, Medical University of Warsaw, Warsaw, Poland

    Anna Stochmal, Joanna Czuwara, Michał Zaremba & Lidia Rudnicka

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Stochmal, A., Czuwara, J., Zaremba, M. et al. Epoprostenol up-regulates serum adiponectin level in patients with systemic sclerosis: therapeutic implications. Arch Dermatol Res 313, 783–791 (2021). https://doi.org/10.1007/s00403-020-02172-0

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