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Sleep disordered breathing and the risk of psoriasis among US women

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A Letter to the Editor to this article was published on 30 March 2016

Abstract

Sleep disordered breathing [snoring and obstructive sleep apnea–hypopnea syndrome (OSAHS)] is common in the US and has been associated with negative health outcomes. There has been no long-term prospective study on the association between sleep disordered breathing and psoriasis risk. We prospectively evaluated the association between OSAHS and snoring and incident psoriasis and psoriatic arthritis (PsA) in 71,598 women over an 11-year period (1997–2008) in the Nurses’ Health Study. Participants received follow-up questionnaires every 2 years and were asked about snoring, diagnosis of OSAHS, and diagnosis of psoriasis and PsA. We studied individuals who reported data on snoring and OSAHS prior to the diagnosis of psoriasis or PsA. We used Cox proportional hazards to calculate age-adjusted and multivariate risk ratios. Over the follow-up period, there were 524 cases of psoriasis. Women with OSAHS were more likely to have a higher BMI, be hypertensive, have cardiovascular disease, and have type 2 diabetes (p < 0.001 for all). The age-adjusted relative risk (RR) of psoriasis among women with OSAHS was 2.19 (95 % CI 1.39–3.45), the multivariate RR was 1.93 (95 % CI 1.21–3.08). Further adjusting for night shift work, hypertension, cardiovascular disease, and type 2 diabetes, the multivariate RR was 1.91 (95 % CI 1.20–3.05). There was no effect modification by BMI (p = 0.52), hypertension (p = 0.34), or snoring (p = 0.91). OSAHS was not associated with an increased risk of PsA. Although women with OSAHS were more likely to be snorers, we did not find a statistically significant relationship between snoring and the risk of confirmed psoriasis. In this study, we found that women with OSAHS had a significantly increased risk of psoriasis.

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References

  1. Arican O, Aral M, Sasmaz S, Ciragil P (2005) Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. Mediat Inflamm 2005:273–279

    Article  Google Scholar 

  2. Ayas NT, White DP, Al-Delaimy WK, Manson JE, Stampfer MJ, Speizer FE, Patel S, Hu FB (2003) A prospective study of self-reported sleep duration and incident diabetes in women. Diabetes Care 26:380–384

    Article  PubMed  Google Scholar 

  3. Ayas NT, White DP, Manson JE, Stampfer MJ, Speizer FE, Malhotra A, Hu FB (2003) A prospective study of sleep duration and coronary heart disease in women. Arch Intern Med 163:205–209

    Article  PubMed  Google Scholar 

  4. Calvin AD, Albuquerque FN, Lopez-Jimenez F, Somers VK (2009) Obstructive sleep apnea, inflammation, and the metabolic syndrome. Metab Syndr Relat Disord 7:271–278

    Article  PubMed  PubMed Central  Google Scholar 

  5. Dempsey JA, Veasey SC, Morgan BJ, O’Donnell CP (2010) Pathophysiology of sleep apnea. Physiol Rev 90:47–112

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Dominguez PL, Assarpour A, Kuo H, Holt EW, Tyler S, Qureshi AA (2009) Development and pilot-testing of a psoriasis screening tool. Br J Dermatol 161:778–784

    Article  CAS  PubMed  Google Scholar 

  7. Dominguez PL, Husni ME, Holt EW, Tyler S, Qureshi AA (2009) Validity, reliability, and sensitivity-to-change properties of the psoriatic arthritis screening and evaluation questionnaire. Arch Dermatol Res 301:573–579

    Article  PubMed  PubMed Central  Google Scholar 

  8. Gezer O, Batmaz I, Sariyildiz MA, Sula B, Ucmak D, Bozkurt M, Nas K (2014) Sleep quality in patients with psoriatic arthritis. Int J Rheum Dis. doi:10.1111/1756-185X.12505

  9. Gowda S, Goldblum OM, McCall WV, Feldman SR (2010) Factors affecting sleep quality in patients with psoriasis. J Am Acad Dermatol 63:114–123

    Article  PubMed  Google Scholar 

  10. Hiestand DM, Britz P, Goldman M, Phillips B (2006) Prevalence of symptoms and risk of sleep apnea in the US population: results from the national sleep foundation sleep in America 2005 poll. Chest 130:780–786

    Article  PubMed  Google Scholar 

  11. Hu FB, Willett WC, Colditz GA, Ascherio A, Speizer FE, Rosner B, Hennekens CH, Stampfer MJ (1999) Prospective study of snoring and risk of hypertension in women. Am J Epidemiol 150:806–816

    Article  CAS  PubMed  Google Scholar 

  12. Hu FB, Willett WC, Manson JE, Colditz GA, Rimm EB, Speizer FE, Hennekens CH, Stampfer MJ (2000) Snoring and risk of cardiovascular disease in women. J Am Coll Cardiol 35:308–313

    Article  CAS  PubMed  Google Scholar 

  13. Nestle FO, Kaplan DH, Barker J (2009) Psoriasis. N Engl J Med 361:496–509

    Article  CAS  PubMed  Google Scholar 

  14. Papadavid E, Vlami K, Dalamaga M, Giatrakou S, Theodoropoulos K, Gyftopoulos S, Stavrianeas N, Papiris S, Rigopoulos D (2013) Sleep apnea as a comorbidity in obese psoriasis patients: a cross-sectional study. Do psoriasis characteristics and metabolic parameters play a role? J Eur Acad Dermatol Venereol 27:820–826

    Article  CAS  PubMed  Google Scholar 

  15. Patel SR, Ayas NT, Malhotra MR, White DP, Schernhammer ES, Speizer FE, Stampfer MJ, Hu FB (2004) A prospective study of sleep duration and mortality risk in women. Sleep 27:440–444

    PubMed  Google Scholar 

  16. Patel SR, Malhotra A, Gottlieb DJ, White DP, Hu FB (2006) Correlates of long sleep duration. Sleep 29:881–889

    PubMed  PubMed Central  Google Scholar 

  17. Shutty BG, West C, Huang KE, Landis E, Dabade T, Browder B, O’Neill J, Kinney MA, Feneran AN, Taylor S, Yentzer B, McCall WV, Fleischer AB Jr, Feldman SR (2013) Sleep disturbances in psoriasis. Dermatol Online J 19:1

    PubMed  Google Scholar 

  18. Stinco G, Trevisan G, Piccirillo F, Di Meo N, Nan K, Deroma L, Bergamo S, Patrone P (2013) Psoriasis vulgaris does not adversely influence the quality of sleep. G Ital Dermatol Venereol 148:655–659

    CAS  PubMed  Google Scholar 

  19. Svensson M, Venge P, Janson C, Lindberg E (2012) Relationship between sleep-disordered breathing and markers of systemic inflammation in women from the general population. J Sleep Res 21:147–154

    Article  PubMed  Google Scholar 

  20. von Ruesten A, Weikert C, Fietze I, Boeing H (2012) Association of sleep duration with chronic diseases in the European prospective Investigation into cancer and nutrition (EPIC)-Potsdam study. PLoS One 7:e30972

    Article  Google Scholar 

  21. Yang YW, Kang JH, Lin HC (2012) Increased risk of psoriasis following obstructive sleep apnea: a longitudinal population-based study. Sleep Med 13:285–289

    Article  PubMed  Google Scholar 

  22. Yeo Y, Ma SH, Park SK, Chang SH, Shin HR, Kang D, Yoo KY (2013) A prospective cohort study on the relationship of sleep duration with all-cause and disease-specific mortality in the Korean multi-center cancer cohort study. J Prev Med Public Health 46:271–281

    Article  PubMed  PubMed Central  Google Scholar 

  23. Young T, Skatrud J, Peppard PE (2004) Risk factors for obstructive sleep apnea in adults. JAMA 291:2013–2016

    Article  CAS  PubMed  Google Scholar 

  24. Zamarron C, Garcia Paz V, Riveiro A (2008) Obstructive sleep apnea syndrome is a systemic disease. Current evidence. Eur J Intern Med 19:390–398

    Article  PubMed  Google Scholar 

  25. Zhang X, Giovannucci EL, Wu K, Gao X, Hu F, Ogino S, Schernhammer ES, Fuchs CS, Redline S, Willett WC, Ma J (2013) Associations of self-reported sleep duration and snoring with colorectal cancer risk in men and women. Sleep 36:681–688

    PubMed  PubMed Central  Google Scholar 

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Acknowledgments

We are deeply indebted to the participants and staff of the Nurses’ Health Study for their valuable contributions. This work was funded by the National Psoriasis Foundation Medical Dermatology Research Fellowship (JMC), the Department of Dermatology, Brigham and Women’s Hospital, Boston, Massachusetts and National Institutes of Health (NIH) grant R01 CA50385.

Conflict of interest

Dr. Qureshi serves as a consultant for Abbvie, Amgen, the Centers for Disease Control, Janssen, Merck, Novartis, and Pfizer and is an investigator for Amgen. Mr. Cohen, Dr. Jackson, and Ms. Li have no conflicts of interest.

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Authors and Affiliations

  1. Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA

    Jeffrey M. Cohen

  2. Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Building II, Third Floor, Boston, MA, 02115, USA

    Chandra L. Jackson

  3. The Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA

    Tricia Y. Li & Abrar A. Qureshi

  4. Department of Dermatology, Warren Alpert Medical School, Brown University, Box G-D, Providence, RI, 02912, USA

    Shaowei Wu & Abrar A. Qureshi

Authors
  1. Jeffrey M. Cohen
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  2. Chandra L. Jackson
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  3. Tricia Y. Li
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  4. Shaowei Wu
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  5. Abrar A. Qureshi
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Correspondence to Abrar A. Qureshi.

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Cohen, J.M., Jackson, C.L., Li, T.Y. et al. Sleep disordered breathing and the risk of psoriasis among US women. Arch Dermatol Res 307, 433–438 (2015). https://doi.org/10.1007/s00403-015-1536-4

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  • DOI: https://doi.org/10.1007/s00403-015-1536-4

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