Abstract
We aimed to investigate the role of IL-12B gene polymorphism (rs6887695) in the disease susceptibility and clinical phenotypes of psoriasis vulgaris patients in the Chinese Han population. The genotype data of the IL-12B gene polymorphism (rs6887695) in 575 psoriasis patients and 1,403 normal controls were investigated using TaqMan technology. The Chi-square test was used to compare the genotype and allele frequency distribution among the groups. The genotypic and allelic frequencies of rs6887695 in the IL-12B gene between the cases and controls, as well as between the guttate and plaque psoriasis cases, were statistically significant (P genotype <0.01, P allele <0.01). However, the differences between the pediatric and adult onset psoriasis patients, between familial and sporadic cases, and between female and male cases were not statistically significant (P > 0.05). The genetic polymorphism of the IL-12B gene (rs6887695) may be associated with the psoriasis susceptibility in the Chinese Han population, especially for the plaque cases, but not associated with the age at onset, family history, or sex.
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References
Allen MH, Ameen H, Veal C et al (2005) The major psoriasis susceptibility locus PSORS1 is not a risk factor for late-onset psoriasis. J Invest Dermatol 124(1):103–106
Arican O, Aral M, Sasmaz S, Ciragil P (2005) Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. Mediators Inflamm 5:273–279
Barker JN (1991) The pathophysiology of psoriasis. Lancet 338(8761):227–230
Campalani E, Allen MH, Fairhurst D et al (2006) Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin. Br J Dermatol 154(2):345–352
Capon F, di Meglio P, Szaub J et al (2007) Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. Hum Genet 122(2):201–206
Carlén LM, Sánchez F, Bergman AC et al (2005) Proteome analysis of skin distinguishes acute guttate from chronic plaque psoriasis. J Invest Dermatol 124(1):63–69
Cargill M, Schrodi SJ, Chang M et al (2007) A large-scale genetic association study confirm IL12B and leads to the identification of IL23R as psoriasis risk genes. Am J Hum Genet 80(2):273–290
Chang YT, Chou CT, Yu CW et al (2007) Cytokine gene polymorphisms in Chinese patients with psoriasis. Br J Dermatol 156(5):899–905
Cheng J, Tu Y, Li J et al (2001) A study on the expression of interleukin (IL)-10 and IL-12 P35, P40 mRNA in the psoriatic lesions. J Tongji Med Univ 21(1):86–88
Griffiths CE, Barker JN (2007) Pathogenesis and clinical features of psoriasis. Lancet 370:263–271
Giardina E, Sinibaldi C, Novelli G (2007) Mapping the future of common diseases: lessons from psoriasis. Front Biosci 12:1563–1573
Ho PY, Barton A, Worthington J et al (2008) Investigating the role of the HLA-Cw* 06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: comparison with psoriasis and undifferentiated inflammatory arthritis. Ann Rheum Dis 67(5):677–682
Kader HA, Tchernev VT, Satyaraj E et al (2005) Protein microarray analysis of disease activity in pediatric inflammatory bowel disease demonstrates elevated serum PLGF, IL-7, TGF-beta1, and IL-12p40 levels in Crohn’s disease and ulcerative colitis patients in remission versus active disease. Am J Gastroenterol 100(2):414–423
Krämer U, Illig T, Grune T et al (2007) Strong associations of psoriasis with antigen processing LMP and transport genes TAP differ by gender and phenotype. Genes Immun 8(6):513–517
Lee E, Trepicchio WL, Oestreicher JL et al (2004) Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med 199(1):125–130
Lew W, Lee E, Krueger JG (2004) Psoriasis genomics: analysis of proinflammatory (type 1) gene expression in large plaque (Western) and small plaque (Asian) psoriasis vulgaris. Br J Dermatol 150(4):668–676
Liu Y, Helms C, Liao W et al (2008) A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet 4(3):e1000041
Mallon E (2000) Retroviruses and psoriasis. Curr Opin Infect Dis 13(2):103–107
Nair RP, Ruether A, Stuart PE et al (2008) Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. J Invest Dermatol 128(7):1653–1661
Nickoloff BJ (2007) Cracking the cytokine code in psoriasis. Nat Med 13(3):242–244
Raychaudhuri SP, Gross J (2000) A comparative study of pediatric onset psoriasis with adult onset psoriasis. Pediatr Dermatol 17(3):174–178
Wu Y, Lu Z, Chen Y, Xue F, Chen X, Zheng J (2010) Replication of association between interleukin-23 receptor (IL-23R) and its ligand (IL-12B) polymorphisms and psoriasis in the Chinese Han population. Hum Immunol 71(12):1255–1258
Yen D, Cheung J, Scheerens H et al (2006) IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 116(5):1310–1316
Zhang XJ, Huang W, Yang S et al (2009) Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet 41(2):205–210
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Yumei Wu and Zhiyong Lu contributed equally to this paper.
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Wu, Y., Lu, Z., Chen, Y. et al. Association of IL-12B gene rs6887695 polymorphism with hereditary susceptibility and clinical characterization of psoriasis vulgaris in the Chinese Han population. Arch Dermatol Res 305, 477–482 (2013). https://doi.org/10.1007/s00403-013-1342-9
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DOI: https://doi.org/10.1007/s00403-013-1342-9