Skip to main content

Advertisement

Log in

A new view concerning the effects of collagen hydrolysate intake on skin properties

Archives of Dermatological Research Aims and scope Submit manuscript

Abstract

Dietary supplements (vitamins, polyphenols, micronutrients and proteins) have demonstrated beneficial effects on skin health. The classical route of administration of active compounds is by topical application and manufactures have substantial experience of formulating ingredients in this field. However, the use of functional foods or nutraceuticals for improving skin condition is increasing. The preclinical efficacy assays and bioavailability trials provide a basis from which to establish appropriate collagen hydrolysate (CH) intakes that might impact skin health outcomes. This commentary deals essentially with the general aspects of CH, bioavailability and findings of preclinical studies concerning the effects of CH intake on skin. To comprehensively study the different benefits of CH on skin, controlled clinical trials are needed in addition to the previous pre-clinical and bioavailability assays. Gaps in knowledge are identified and suggestions are made for future research.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Barel A, Calomme M, Timchenko A et al (2005) Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin. Arch Dermatol Res 297:147–153. doi:10.1007/s00403-005-0584-6

    Article  PubMed  CAS  Google Scholar 

  2. Baziwane D, He Q (2003) Gelatin: the paramount food additive. Food Rev Int 19:423–435. doi:10.1081/FRI-120025483

    Article  CAS  Google Scholar 

  3. Boelsma E, van de Vijver LPL, Goldbohm RA et al (2003) Human skin condition and its associations with nutrient concentrations in serum and diet. Am J Clin Nutr 77:348–355

    PubMed  CAS  Google Scholar 

  4. Boullin DJ, Crampton RF, Heading CE, Pelling D (1973) Intestinal absorption of dipeptides containing glycine, phenylalanine, proline, beta-alanine or histidine in the rat. Clin Sci Mol Med 45:49–58

    PubMed  CAS  Google Scholar 

  5. Chiu AE, Chan JL, Kern DG et al (2005) Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin. Dermatol Surg 31:855–859

    PubMed  CAS  Google Scholar 

  6. Cosgrove MC, Franco OH, Granger SP et al (2007) Dietary nutrient intakes and skin-aging appearance among middle-aged American women. Am J Clin Nutr 86:1225–1231

    PubMed  CAS  Google Scholar 

  7. Djagny KB, Wang Z, Xu S (2001) Gelatin: A valuable protein for food and pharmaceutical industries. Crit Rev Food Sci Nutr 41:481–492. doi:10.1080/20014091091904 Review

    Article  PubMed  CAS  Google Scholar 

  8. Fuchs J (1998) Potentials and limitations of the natural antioxidants RRR-alpha-tocopherol, l-ascorbic acid and β-carotene in cutaneous photoprotection. Free Radic Biol Med 25:848–873. doi:10.1016/S0891-5849(98)00161-0

    Article  PubMed  CAS  Google Scholar 

  9. Heinrich U, Tronnier H, Stahl W et al (2006) Antioxidant supplements improve parameters related to skin structure in humans. Skin Pharmacol Physiol 19:224–231. doi:10.1159/000093118

    Article  PubMed  CAS  Google Scholar 

  10. Iwai K, Hasegawa T, Taguchi Y et al (2005) Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. J Agric Food Chem 53:6531–6536. doi:10.1021/jf050206p

    Article  PubMed  CAS  Google Scholar 

  11. Kieffer ME, Efsen J (1998) Imedeen® in the treatment of photoaged skin: an efficacy and safety trial over 12 months. J Eur Acad Dermatol Venereol 11:129–136

    PubMed  CAS  Google Scholar 

  12. Kim SK, Byun HG, Park PJ, Shahidi F (2001) Angiotensin I converting enzyme inhibitory peptides purified from bovine skin gelatin hydrolysate. J Agric Food Chem 49:2992–2997. doi:10.1021/jf001119u

    Article  PubMed  CAS  Google Scholar 

  13. Kim SK, Kim YT, Byun HG et al (2001) Purification and characterization of antioxidative peptides from bovine skin. J Biochem Mol Biol 34:219–224

    CAS  Google Scholar 

  14. Laskin DL, Kimura T, Sakakibara S et al (1986) Chemotactic activity of collagen-like polypeptides for human peripheral blood neutrophils. J Leukoc Biol 39:255–266

    PubMed  CAS  Google Scholar 

  15. Li B, Chen F, Wng X et al (2007) Isolation and identification of antioxidant peptides from porcine collagen hydrolysate by consecutive chromatography and electrospray ionization-mass spectrometry. Food Chem 102:1135–1143. doi:10.1016/j.foodchem.2006.07.002

    Article  CAS  Google Scholar 

  16. Matsuda N, Koyama Y, Hosaka Y et al (2006) Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis. J Nutr Sci Vitaminol (Tokyo) 52:211–215. doi:10.3177/jnsv.52.211

    Article  CAS  Google Scholar 

  17. Matthews DM, Laster L (1965) Absorption of protein digestion products: a review. Gut 6:411–426. doi:10.1136/gut.6.5.411

    Article  PubMed  CAS  Google Scholar 

  18. Mendis E, Rajapakse N, Kim S-K (2005) Antioxidant properties of a radical-scavenging peptide purified from enzymatically prepared fish skin gelatin hydrolysate. J Agric Food Chem 53:581–587. doi:10.1021/jf048877v

    Article  PubMed  CAS  Google Scholar 

  19. Minaguchi J, Koyama Y, Meguri N et al (2005) Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in Achilles tendon. J Nutr Sci Vitaminol (Tokyo) 51:169–174

    CAS  Google Scholar 

  20. Morganti P, Randazzo SD (1984) Nutrition and hair. J Appl Cosmetol 2:41–49

    CAS  Google Scholar 

  21. Moskowitz RW (2000) Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum 30:87–99. doi:10.1053/sarh.2000.9622

    Article  PubMed  CAS  Google Scholar 

  22. Nemati M, Oveisi MR, Abdollahi H, Sabzevari O (2004) Differentiation of bovine and porcine gelatins using principal component analysis. J Pharm Biomed Anal 34:485–492. doi:10.1016/S0731-7085(03)00574-0

    Article  PubMed  CAS  Google Scholar 

  23. Oesser S, Adam M, Babel W, Seifert J (1999) Oral administration of 14C labeled collagen hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL). J Nutr 129:1891–1895

    PubMed  CAS  Google Scholar 

  24. Oesser S, Seifert J (2003) Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Cell Tissue Res 311:393–399

    PubMed  CAS  Google Scholar 

  25. Ohara H, Matsumoto H, Ito K et al (2007) Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources. J Agric Food Chem 55:1532–1535. doi:10.1021/jf062834s

    Article  PubMed  CAS  Google Scholar 

  26. Postlethwaite AE, Kang A (1976) Collagen and collagen peptide induced chemotaxis of human blood monocytes. J Exp Med 143:1299–1307. doi:10.1084/jem.143.6.1299

    Article  PubMed  CAS  Google Scholar 

  27. Postlethwaite AE, Seyer JM, Kang AH (1978) Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proc Natl Acad Sci USA 75:871–875. doi:10.1073/pnas.75.2.871

    Article  PubMed  CAS  Google Scholar 

  28. Richelle M, Sabatier M, Steiling H, Williamson G (2006) Skin bioavailability of dietary vitamin E, carotenoids, polyphenols, vitamin C, zinc and selenium. Br J Nutr 96:227–238. doi:10.1079/BJN20061817

    Article  PubMed  CAS  Google Scholar 

  29. Rosenberg SW (1957) Further studies in the use of gelatin in the treatment of brittle nails. AMA Arch Derm 76:330–335

    PubMed  CAS  Google Scholar 

  30. Scala J, Hollies NRS, Sucher KP (1976) Effect of daily gelatin ingestion on human scalp hair. Nutr Rep Int 13:579–592

    CAS  Google Scholar 

  31. Skovgaard GR, Jensen AS, Sigler ML (2006) Effect of a novel dietary supplement on skin aging in post-menopausal women. Eur J Clin Nutr 60:1201–1206. doi:10.1038/sj.ejcn.1602438

    Article  PubMed  CAS  Google Scholar 

  32. Sumida E, Hirota A, Kuwaba K et al (2004) The effect of oral ingestion of collagen peptide on skin hydration and biochemical data of blood. J Nutr Food 7:45–52

    Google Scholar 

  33. Thom E (2001) Efficacy and tolerability of Hairgain® in individuals with hair loss: a placebo-controlled, double-blind study. J Int Med Res 29:2–6

    PubMed  CAS  Google Scholar 

  34. Thom E (2005) A randomized, double-blind, placebo-controlled study on the clinical efficacy of oral treatment with Dermavite™ on ageing symptoms of the skin. J Int Med Res 33:267–272

    PubMed  CAS  Google Scholar 

  35. Tyson TL (1950) The effect of gelatin on fragile finger nails. J Invest Dermatol 14:323–325

    PubMed  CAS  Google Scholar 

  36. Wu J, Fujioka M, Sugimoto K (2004) Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats. J Bone Miner Metab 22:547–553. doi:10.1007/s00774-004-0522-2

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Vivian Zague.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zague, V. A new view concerning the effects of collagen hydrolysate intake on skin properties. Arch Dermatol Res 300, 479–483 (2008). https://doi.org/10.1007/s00403-008-0888-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00403-008-0888-4

Keywords

Navigation