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Preparation and properties of marine-derived sphingan WL gum-metal ion composite hydrogels

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Abstract

Sphingan WL gum produced by marine Sphingomonas sp. WG is a new kind of extracellular polysaccharide reported by our group in 2016. This work selected five metal ions, Na+, Zn2+, Ca2+, Cu2+, and Fe3+, to prepare sphingan WL gum-metal ion (WL-M) composite hydrogels by immersion-adsorption method for the first time. With the increase of immersion solution concentration, the volume of WL-M shrinks, the water content decreases, and the content of metal ions increases. WL-Na2, with the highest water content (91.81%), has the lowest metal ion content (20.76 mg/g); WL-Cu4, with the highest metal ion content (99.80 mg/g), has the lowest water content (73.07%). The results of inductively coupled plasma optical emission spectroscopy show that the adsorption capacity (mg/g) of metal ions by WL is in the order of Cu2+ > Zn2+ > Fe3+ > Ca2+ > Na+. Fourier transform infrared and X-ray photoelectron spectroscopy results suggest that carboxyl and hydroxyl groups are the main active sites of WL interacting with metal ions. The rheological test results reveal that the order of cross-linking effect is Ca2+ > Fe3+ > Cu2+ > Zn2+ > Na+. The G' of WL-Ca4 is the largest, reaching 154.9 Pa at 1 rad/s. The metal ion release behavior was found to follow the Korsmeyer-Peppas model (R2 > 0.97, n < 0.43) and be pH responsive. WL-Ca3 shows good biocompatibility, self-healing, and injectable properties. The above results indicate that the WL-Ca hydrogels have the most promising application prospects in biomedicine and deserve further research.

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The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Funding

This work was financially supported by the Natural Science Foundation of China (U1805234 and 22007013), Fujian-Taiwan Science and Technology Cooperation Base of Biomedical Materials and Tissue Engineering (2021D039), Natural Science Foundation of Fujian Province of China (2020J05033), Program for Innovative Research Team in Science and Technology in Fujian Province University, 100 Talents Program of Fujian Province, and Scientific Research Start-up Fund for High-Level Talents in Fujian Normal University.

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Authors and Affiliations

  1. Fujian-Taiwan Science and Technology Cooperation Base of Biomedical Materials and Tissue Engineering, Engineering Research Center of Industrial Biocatalysis, Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, Fujian, 350007, China

    Jinfeng Deng, Jieying Lin, Zhenyin Huang, Aiping Chang & Hu Zhu

  2. Zaozhuang Jienuo Enzyme Co., Ltd, Zaozhuang, Shandong, 277015, China

    Xiangyang Xu

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  1. Jinfeng Deng
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Conceptualization, Aiping Chang and Hu Zhu; Investigation, Jinfeng Deng and Aiping Chang; Data curation, Jieying Lin, Zhenyin Huang and Xiangyang Xu; Writing – original draft, Aiping Chang and Jinfeng Deng; Writing – review & editing, Aiping Chang and Hu Zhu. All authors have read and agreed to the published version of the manuscript.

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Deng, J., Lin, J., Huang, Z. et al. Preparation and properties of marine-derived sphingan WL gum-metal ion composite hydrogels. Colloid Polym Sci 301, 1115–1124 (2023). https://doi.org/10.1007/s00396-023-05133-x

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