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Aktueller Stellenwert der Stammzelltransplantation bei Autoimmunerkrankungen

Current value of stem-cell transplantation in autoimmune diseases

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Zusammenfassung

Die autologe oder allogene Transplantation peripherer Blutstammzellen aus dem Knochenmark oder peripheren Blut wird bei therapierefraktären Autoimmunerkrankungen durchgeführt. Seit 1996 werden Daten systematisch gesammelt. Wir beschreiben die historische Entwicklung dieses Verfahrens für Autoimmunerkrankungen, die möglichen Wirkmechanismen sowie die Möglichkeiten der Stammzellsammlung und der Konditionierung (Hochdosis-Chemotherapie, Kombination mit monoklonalen Anti-T- oder -B-Zell-Antikörpern, Ganzkörperbestrahlung) und die in der Literatur berichteten Ergebnisse.

Abstract

Transplantations of autologous or allogeneic stem cells from bone marrow or peripheral blood are preformed for the treatment of resistant autoimmune diseases. Data have been systematically collected since 1996. We describe the historical development of this procedure for autoimmune diseases, the possible mechanisms of action, the options for stem cell collection, purging and conditioning (high-dose chemotherapy, combination with monoclonal anti-T- or B-cell antibodies, total body irradiation), as well as the reported outcomes in the literature.

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  1. Abteilung Innere Medizin II (Hämatologie, Onkologie, Immunologie, Rheumatologie und Pulmologie), Medizinische Universitätsklinik Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Deutschland

    I. Kötter, M. Schmalzing, J. Henes, W. Vogel & L. Kanz

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  1. I. Kötter
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  2. M. Schmalzing
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Correspondence to I. Kötter.

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Kötter, I., Schmalzing, M., Henes, J. et al. Aktueller Stellenwert der Stammzelltransplantation bei Autoimmunerkrankungen. Z. Rheumatol. 67, 716–722 (2008). https://doi.org/10.1007/s00393-008-0386-2

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