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Revision: prognostic impact of baseline glucose levels in acute myocardial infarction complicated by cardiogenic shock—a substudy of the IABP-SHOCK II-trial

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A Correction to this article was published on 28 February 2018

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Abstract

Background

Limited data from observational retrospective studies suggest an association between glucose levels and prognosis of patients with cardiogenic shock (CS). The aim of this study was to investigate the prognostic role of glucose at admission in patients with acute myocardial infarction (AMI) complicated by CS included in the largest CS trial to date, the Intraaortic Balloon Pump in Cardiogenic Shock II (IABP-SHOCK II) trial.

Methods and results

In the IABP-SHOCK II-trial, patients with CS complicating AMI undergoing early revascularization were randomized to a therapy with vs. without IABP support. Primary and secondary endpoints were mortality within 30 days and 1 year, respectively. Glucose levels were examined at admission. Glucose levels were available in 513 patients. In total, 33.7% of the patients had known diabetes. Patients with diabetes had higher glucose levels compared to those without diabetes (median [interquartile range (IQR)] 13.1 mmol/L [IQR 9.5–18.3] vs. 10.8 mmol/L [IQR 7.8–15.4], p = 0.0003). Patients with glucose concentrations above the median (11.5 mmol/L) had higher 30-day and 1-year mortality compared to those below the median (47.7 vs. 36.5%, p = 0.004; 57.7 vs. 47.1%, p = 0.011, respectively). This negative prognostic impact of increased glucose levels remained significant in multivariate adjustment and was not influenced even after adjustment for the presence or absence of diabetes mellitus.

Conclusions

In patients with CS complicating AMI, increased glucose concentration at admission was an independent predictor for mortality at 30-days and 1-year, independently of the diabetic state.

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Change history

  • 28 February 2018

    The title of this article was rendered incorrectly; the correct title is as follows:

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Author notes

  1. Amr Abdin and Janine Pöss contributed equally to this manuscript.

Authors and Affiliations

  1. Medical Clinic II (Cardiology/Angiology/Intensive Care Medicine), University Heart Centre Luebeck, Luebeck, Germany

    Amr Abdin, Janine Pöss, Georg Fuernau, Ingo Eitel & Suzanne de Waha

  2. German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Luebeck, Luebeck, Germany

    Janine Pöss, Georg Fuernau, Ingo Eitel & Suzanne de Waha

  3. Institut für Herzinfarktforschung, Ludwigshafen, Germany

    Taoufik Ouarrak

  4. Klinikum Ludwigshafen and Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen, Germany

    Uwe Zeymer

  5. Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany

    Michael Böhm

  6. Department of Internal Medicine/Cardiology, University of Leipzig-Heart Centre Leipzig, Strümpellstr. 39, 04289, Leipzig, Germany

    Steffen Desch & Holger Thiele

Authors
  1. Amr Abdin
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  2. Janine Pöss
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  3. Georg Fuernau
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  4. Taoufik Ouarrak
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  5. Steffen Desch
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  6. Ingo Eitel
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  7. Suzanne de Waha
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  8. Uwe Zeymer
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  9. Michael Böhm
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  10. Holger Thiele
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Correspondence to Holger Thiele.

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All authors declared that they have no competing interest.

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Abdin, A., Pöss, J., Fuernau, G. et al. Revision: prognostic impact of baseline glucose levels in acute myocardial infarction complicated by cardiogenic shock—a substudy of the IABP-SHOCK II-trial. Clin Res Cardiol 107, 517–523 (2018). https://doi.org/10.1007/s00392-018-1213-7

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  • DOI: https://doi.org/10.1007/s00392-018-1213-7

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