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Diagnostic value of spiral CT energy spectrum imaging in lymph node metastasis of colorectal cancer

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Objectives

To evaluate the value of preoperative CT energy spectrum imaging in detecting lymph node metastasis of colorectal cancer.

Methods

From September 2019 to November 2021, a retrospective study was performed for the eighty-two patients with colorectal cancer through preoperative colonoscopy or surgical pathology confirmed in our hospital. Based on the lymph node metastasis status, these cases were divided into the metastasis and non-metastasis groups. GE Revolution CT scanner was used to scan the patients with energy spectrum imaging, it measured and recorded the single-energy CT values from 40 to 140 keV and various energy spectrum parameters of lymph nodes around the lesions in the arterial and venous phases, and statistically analyze the above indices.

Results

In the arterial and venous phases: the single-energy CT values of 40–140 keV in the non-metastatic group were higher than those in the metastatic group (all P < 0.05); the parameter values of IC (iodine concentration), NIC (normalized iodine concentration), λ (the slope of the energy spectrum curve), and Eff-Z (effective-Z) in the non-metastatic group were higher than those in the metastatic group (all P < 0.05). Further evaluation of ROC curve showed that the higher AUC (area under curve) of the single-energy CT value of 50 keV in the arterial phase was 0.889, among the energy spectrum parameters of IC, NIC, λ, and Eff-Z, the NIC had the better diagnostic efficiency and the AUC of the NIC was 0.873, the highest AUC of the combination of NIC and λ was 0.885 when the energy spectrum parameters were combined. The higher AUC of the single-energy CT value of 60 keV in the venous phase was 0.853, among the energy spectrum parameters of IC, NIC, λ, and Eff-Z, the λ had the better diagnostic efficiency and the AUC of the λ was 0.822, the higher AUC of the combination of NIC, λ, and Eff-Z was 0.840 when the energy spectra were combined.

Conclusions

Parameters of energy spectrum CT imaging can effectively evaluate whether lymph nodes have metastases, and provide favorable imaging diagnosis basis for the range and the number of lymph nodes to be cleaned during clinical operation and can evaluate the prognosis of patients. It is worthy of clinical recommendation.

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References

  1. Sengupta R, Zaidi SK (2021) AACR Cancer Progress Report 2021: discovery science driving clinical breakthroughsAACR cancer progress report 2021. Clin Cancer Res 27(21):5757–5759

    Article  Google Scholar 

  2. Iinuma G, Miyake M, Arai Y et al (2008) CT colonographytowards applications for colorectal cancer screening. Asian Pac J Cancer Prev 9(4):833–840

    PubMed  Google Scholar 

  3. Hansen J, Jurik AG (2009) Analysis of current practice of CT examinations. Acta Oncol 48(2):295–301

    Article  Google Scholar 

  4. Lin S, Luo G, Gao X et al (2011) Application of endoscopic sonography in preoperative staging of rectal cancer: six-year experience. J Ultrasound Med 30(8):1051–1057

    Article  Google Scholar 

  5. Gao Y, Wang J, Lv H et al (2019) Diagnostic value of magnetic resonance and computed tomography colonography for the diagnosis of colorectal cancer: a systematic review and meta-analysis. Medicine 98(39)

  6. Kijima S, Sasaki T, Nagata K et al (2014) Preoperative evaluation of colorectal cancer using CT colonography, MRI and PET/CT. World J Gastroenterol 20(45):16964–16975

    Article  Google Scholar 

  7. Ippolito D, Drago SG, Franzesi CT et al (2016) Rectal cancer staging: multidetector-row computed tomography diagnostic accuracy in assessment of mesorectal fascia invasion. World J Gastroenterol 22(20):4891–4900

    Article  Google Scholar 

  8. Jin M, Frankel WL (2018) Lymph node metastasis in colorectal cancer. Surg Oncol Clin 27(2):401–412

    Article  Google Scholar 

  9. Tran C, Howlett C, Driman DK (2020) Evaluating the impact of lymph node resampling on colorectal cancer nodal stage. Histopathology 77(6):974–983

    Article  Google Scholar 

  10. Xie ZY, Chai RM, Ding GC et al (2018) T and N Staging of gastric cancer using dual-source computed tomography. Gastroenterol Res Pract 2018:1–10

    Google Scholar 

  11. Pan XF, Wang L, Pan A (2021) Epidemiology and determinants of obesity in China [published correction appears in Lancet Diabetes Endocrinol. Lancet Diabetes Endocrinol 9(6):373–392

    Article  Google Scholar 

  12. Chen XH, Ren K, Liang P et al (2017) Spectral computed tomography in advanced gastric cancer: can iodine concentration non-invasively assess angiogenesis? World J Gastroenterol 23(9):1666–1675

    Article  CAS  Google Scholar 

  13. Tawfik AM, Razek AA, Kerl JM et al (2014) Comparison of dual-energy CT-derived iodine content and iodine overlay of normal, inflammatory and metastatic squamous cell carcinoma cervical lymph nodes. Eur J Radiol 24(3):574–580

    Article  Google Scholar 

  14. Naresh KN, Nerurkar AY, Borges AM (2001) Angiogenesis is redundant for tumour growth in lymph node metastases. Histopathology 38(5):466–470

    Article  CAS  Google Scholar 

  15. Grancher A, Michel P, Di Fiore F et al (2018) Aspirine et cancer colorectal. Bull Cancer 105(2):171–180

    Article  Google Scholar 

  16. Bosetti C, Santucci C, Gallus S et al (2020) Aspirin and the risk of colorectal and other digestive tract cancers: an updated meta-analysis through 2019. Ann Oncol 31(5):558–568

    Article  CAS  Google Scholar 

  17. Tsoi KKF, Ho JMW, Chan FCH et al (2019) Long-term use of low-dose aspirin for cancer prevention: a 10-year population cohort study in Hong Kong. Int J Cancer 145(1):267–273

    Article  CAS  Google Scholar 

  18. Millien VO, Mansour NM (2020) Bowel preparation for colonoscopy in 2020: a look at the past, present, and future. Curr Gastroenterol Rep 22(6):1–9

    Article  Google Scholar 

  19. Kim SY, Kim HS, Park HJ (2019) Adverse events related to colonoscopy: global trends and future challenges. World J Gastroenterol 25(2):190–204

    Article  Google Scholar 

  20. Liu H, Yan F, Pan Z et al (2015) Evaluation of dual energy spectral CT in differentiating metastatic from non-metastatic lymph nodes in rectal cancer: Initial experience. Eur J Radiol 84(2):228–234

    Article  Google Scholar 

  21. Zou Y, Zheng M, Qi Z et al (2021) Dual-energy computed tomography could reliably differentiate metastatic from non-metastatic lymph nodes of less than 0.5 cm in patients with papillary thyroid carcinoma. Quant Imaging Med Surg 11(4):1354–1367

    Article  Google Scholar 

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Authors and Affiliations

  1. Graduate School, Tianjin Medical University, Tianjin, 300070, China

    Wei-bin Chen & Li-qing Kang

  2. North China University of Science and Technology, Tangshan, 063000, Hebei, China

    Wei-bin Chen, Qian-qian Shi, Ze-mao Li & Zhong-yao Li

  3. Department of Medical Imaging, Cangzhou Central Hospital, Cangzhou Teaching Hospital of Tianjin Medical University, Cangzhou, 061001, Hebei, China

    Li-qing Kang

Authors
  1. Wei-bin Chen
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Weibin Chen, Qianqian Shi, Zemao Li, Zhongyao Li, and Liqing Kang. The first draft of the manuscript was written by Weibin Chen and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Li-qing Kang.

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Ethics approval and consent to participate

This study was approved by the ethics committee at Medical ethics committee of North China University of Science and Technology Affiliated Hospital. Date of approval: December 7, 2021. Approval number: 202112070003.

Conflict of interest

The authors declare no competing interests.

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Chen, Wb., Shi, Qq., Li, Zm. et al. Diagnostic value of spiral CT energy spectrum imaging in lymph node metastasis of colorectal cancer. Int J Colorectal Dis 37, 2021–2029 (2022). https://doi.org/10.1007/s00384-022-04238-z

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