Abstract
Aim of the study
To evaluate the incidence of respiratory failure requiring ECMO in newborns with gastroschisis (GC), compare it to the incidence in the general population, review the surgical outcomes of newborns with GC requiring ECMO and compare them to newborns with GC not requiring ECMO.
Methods
This is a retrospective review of all neonatal admissions for GC from December 2010 to September 2015.
Main results
110 newborns with GC were admitted to our NICU between 12/2010 and 9/2015; 36 were term. Four cases, all term, all prenatally diagnosed, all outborn, developed respiratory failure requiring ECMO secondary to meconium aspiration syndrome (MAS). This 11% (4/36 term GC) represents a 300-fold increase in the incidence of MAS-associated respiratory failure requiring ECMO compared to the general population of term newborns (0.037%). Median time on ECMO was 12 (9–20) days. The time to achieve full enteral feedings in the GC/ECMO group was twice the time of the 106 newborns in the GC/non-ECMO group [median: 70 (48–77) vs. 35 (16–270) days, respectively]. Time to hospital discharge was three times longer in the GC/ECMO group compared to the GC/non-ECMO group (median: 42 [20–282] versus 125 [69–223] days, respectively). All patients survived.
Conclusion
The incidence of respiratory failure requiring ECMO is remarkably higher in patients with GC than in the general population and much higher in the subgroup of term GC. While infrequent, the possibility of this event supports the concept that fetuses with GC benefit from being delivered at tertiary centers with immediate pediatric surgery and ECMO capabilities.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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This article was a retrospective chart review and does not contain any studies with human participants or animals performed by any of the authors.
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Russell, K.W., Nance, M.L., Adzick, N.S. et al. Meconium aspiration syndrome requiring ECMO in newborns with gastroschisis: incidence and surgical outcomes. Pediatr Surg Int 35, 469–472 (2019). https://doi.org/10.1007/s00383-018-4419-x
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DOI: https://doi.org/10.1007/s00383-018-4419-x