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Primary intracranial smooth muscle tumor associated with Epstein-Barr virus in immunosuppressed children: two cases report and review of literature

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Abstract

Primary intracranial smooth muscle tumors are rare. Most cases are related to Epstein-Barr virus proliferation in immunocompromised patients such as organ solid recipients. Only a few cases have been reported in pediatric patients. The clinical features are very variable depending mainly on the location and size of the smooth muscle tumor (SMT) and the pathogenesis is poorly understood. We describe two cases of intracranial SMT localized in the temporal lobe and associated with EBV in immunosuppressed children. A review of the literature associated with intracranial leiomyomas was also done.

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Acknowledgements

The authors would like to acknowledge Dr. Juan Jose Marengo for playing a key role in the approach and treatment of the reported cases.

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Authors and Affiliations

  1. Pediatric Neurosurgery Department, Dr. Asenjo Neurosurgical Institute, Santiago, Chile

    Maximiliano Paez-Nova, Osvaldo Koller & Sergio Valenzuela

  2. Radioneurosurgery and Functional Neurosurgery Unit, Sheba Medical Center, Ramat Gan, Israel

    Maximiliano Paez-Nova

  3. Sheba Medical Center at Tel HaShomer, Tel Aviv University, Tel Aviv, Israel

    Maximiliano Paez-Nova

  4. Pediatric Neurology Department, University of Santiago de Chile, Santiago, Chile

    Karem Andaur

  5. Latin American Council of Neurocritical Care-CLaNi, Cartagena, Colombia

    Ezequiel García-Ballestas & Luis Rafael Moscote-Salazar

  6. Center of Biomedical Research-CIB, Faculty of Medicine, University of Cartagena, Cartagena, Colombia

    Ezequiel García-Ballestas, Diego Bustos-Salazar & Luis Rafael Moscote-Salazar

  7. Pediatric Neurosurgery Department, Alemana Clinic, Santiago, Chile

    Osvaldo Koller & Sergio Valenzuela

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  1. Maximiliano Paez-Nova
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Paez-Nova, M., Andaur, K., García-Ballestas, E. et al. Primary intracranial smooth muscle tumor associated with Epstein-Barr virus in immunosuppressed children: two cases report and review of literature. Childs Nerv Syst 37, 3923–3932 (2021). https://doi.org/10.1007/s00381-021-05173-0

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