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Elimination of medically intractable epileptic drop attacks following endoscopic total corpus callosotomy in Rett syndrome

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Abstract

Introduction

Rett syndrome is a neurodevelopmental genetic disorder, characterized by developmental delay, hand stereotypies, abnormal gait, and acquired microcephaly. Epilepsy is very common in Rett syndrome and can be medically intractable. It remains uncertain if a patient with epileptic drop attacks associated with this genetic disease can benefit from corpus callosotomy.

Case report

We report an 8-year-old girl with Rett syndrome and medically intractable epileptic drop attacks who underwent endoscopic total corpus callosotomy without any complications that led to the successful elimination of her seizures.

Conclusion

Total corpus callosotomy is a feasible treatment option for medically intractable epileptic drop attacks in Rett syndrome and should not be considered as a contraindication in this condition. This is the first reported case of corpus callosotomy in Rett syndrome.

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Acknowledgements

Dr. Asano is supported by NIH grants NS64033 (to E. Asano). Dr. Ueda, Dr. Luat, Dr. Kumar, and Dr. Sood have no funding or sponsorship obtained for producing this manuscript.

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Authors and Affiliations

  1. Division of Neurology, Carman and Ann Adams Department of Pediatrics, Children’s Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI, 48201, USA

    Keisuke Ueda, Eishi Asano & Aimee F. Luat

  2. Wayne State University School of Medicine, 540 E Canfield St, Detroit, MI, 48201, USA

    Keisuke Ueda, Sandeep Sood, Eishi Asano, Ajay Kumar & Aimee F. Luat

  3. Department of Pediatric Neurosurgery, Children’s Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI, 48201, USA

    Sandeep Sood

  4. Department of Radiology, Children’s Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI, 48201, USA

    Ajay Kumar

Authors
  1. Keisuke Ueda
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  2. Sandeep Sood
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  3. Eishi Asano
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  4. Ajay Kumar
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  5. Aimee F. Luat
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Corresponding author

Correspondence to Aimee F. Luat.

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All authors report no conflict of interest to disclose.

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Ueda, K., Sood, S., Asano, E. et al. Elimination of medically intractable epileptic drop attacks following endoscopic total corpus callosotomy in Rett syndrome. Childs Nerv Syst 33, 1883–1887 (2017). https://doi.org/10.1007/s00381-017-3567-y

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  • DOI: https://doi.org/10.1007/s00381-017-3567-y

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