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Higher non-cardiac mortality and lesser impact of early revascularization in patients with type 2 compared to type 1 acute myocardial infarction: results from the Tokyo CCU Network registry

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Abstract

As the definition of type 2 acute myocardial infarction (AMI) is obscure, the characteristics of this disease vary among studies. The clinical significance of type 2 AMI is unclear. We surveyed the Tokyo Cardiovascular Care Unit (CCU) Network registry between 2010 and 2014. The difference in clinical characteristics and the impact of revascularization in patients with type 1 and type 2 AMI were evaluated. The cohort study included 12514 patients admitted to CCU (type 1 AMI, 12023; type 2 AMI, 491; mean age, 68 ± 15 years; 75% male). Coronary angiography was performed in 11402 patients (95%) with type 1 AMI and 427 (87%) with type 2 AMI (p < 0.001). Type 2 AMI was associated with higher in-hospital mortality (type 1 AMI, 769 (6.4%); type 2 AMI, 54 (11.0%); adjusted odds ratio (OR) 1.64; 95% confidence interval (CI) 1.12–2.41; p = 0.011) and higher non-cardiac mortality (adjusted OR 2.19; 95% CI 1.33–3.62; p = 0.002), but similar cardiac mortality rate compared to type 1 AMI (adjusted OR 1.17; 95% CI 0.71–1.91; p = 0.539). Percutaneous coronary intervention (PCI) within 24 h after the onset was associated with lower in-hospital mortality in those with type 1 AMI (OR 0.47; 95% CI 0.40–0.55; p < 0.001), but not in those with type 2 AMI (OR 1.09; 95% CI 0.62–1.94; p = 0.763). The results persisted after adjustment for multivariate logistic regression analysis and inverted probability weighting. In conclusion, patients with type 2 AMI had higher in-hospital mortality owing to higher non-cardiac death. More refined definitions focusing on the treatment of comorbidities may be required, as the treatment strategy for type 2 AMI can be different from that for type 1 AMI.

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Acknowledgements

Financial support for this study was provided by the Tokyo Metropolitan Government, and JSPS KAKENHI Grant number 17K18085 [S.H.]. We thank all the cardiologists and staff participating in the Tokyo CCU Network and Ms. Nobuko Yoshida (Tokyo CCU Network office) for data acquisition.

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Authors and Affiliations

  1. Tokyo CCU Network Scientific Committee, Tokyo, Japan

    Satoshi Higuchi, Makoto Suzuki, Yu Horiuchi, Hiroyuki Tanaka, Mike Saji, Hideaki Yoshino, Ken Nagao, Takeshi Yamamoto & Morimasa Takayama

  2. Department of Cardiology, Kyorin University Hospital, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-0004, Japan

    Satoshi Higuchi

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  1. Satoshi Higuchi
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Correspondence to Satoshi Higuchi.

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Higuchi, S., Suzuki, M., Horiuchi, Y. et al. Higher non-cardiac mortality and lesser impact of early revascularization in patients with type 2 compared to type 1 acute myocardial infarction: results from the Tokyo CCU Network registry. Heart Vessels 34, 1140–1147 (2019). https://doi.org/10.1007/s00380-019-01350-z

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