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Operative Therapie und Bestrahlung konjunktivaler Melanome

Operative therapy and irradiation of conjunctival melanoma

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Zusammenfassung

Hintergrund

Die Strahlentherapie des Bindehautmelanoms hat in den vergangenen Jahren gegenüber weniger invasiven therapeutischen Ansätzen an Bedeutung gewonnen. Das liegt an den erheblichen Rezidivraten, die bei fehlender adjuvanter Therapie erzielt werden, und an der zunehmenden Verfügbarkeit adäquater strahlentherapeutischer Methoden. Damit können auch Tumore bestrahlt werden, die zuvor nicht organerhaltend therapiert werden konnten.

Zielsetzung

Die Arbeit beschreibt die aktuellen Bestrahlungstechniken für die Therapie von Bindehautmelanomen. Ziel der Arbeit ist es, die diagnostischen und therapeutischen Strategien und Abläufe bei der Behandlung von malignen Bindehautmelanomen darzustellen. Es ist den Autoren wichtig, die Notwendigkeit einer adjuvanten Behandlung zu begründen und die interdisziplinäre Zusammenarbeit im Verlauf der Tumortherapie aufzuzeigen.

Methoden

Die Arbeit basiert auf Ergebnissen aus der Literatur ebenso wie auf eigenen Erfahrungen und Daten des Zentrums.

Abstract

Background

Radiotherapy of conjunctival melanoma has gained in importance in recent years compared to less invasive therapeutic approaches. This is due to the high recurrence rates achieved by omitting adjuvant therapy and to the increasing availability of suitable radiotherapeutic methods, so that tumors formerly not amenable to organ-preserving therapy can now be treated.

Objective

This article presents the current radiotherapeutic options for conjunctival melanoma. The aim is to describe the diagnostic and therapeutic strategies and the course of therapy of malignant conjunctival melanoma. It is the authors’ intention to justify the necessity of the adjuvant therapy of conjunctival melanoma and to emphasize the need for interdisciplinary cooperation during the course of tumor therapy.

Methods

The article is based on results published in the literature as well as on data collected and experience gained in our centre.

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Correspondence to H. Westekemper.

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Interessenkonflikt

H. Westekemper, D. Meller, R. Darawsha, S.L. Scholz, D. Flühs, K.-P. Steuhl, J. Hérault, J. Thariat und W. Sauerwein geben an, dass kein Interessenkonflikt besteht.

Alle im vorliegenden Manuskript beschriebenen Untersuchungen am Menschen wurden mit Zustimmung der zuständigen Ethik-Kommission, im Einklang mit nationalem Recht sowie gemäß der Deklaration von Helsinki von 1975 (in der aktuellen, überarbeiteten Fassung) durchgeführt. Von allen beteiligten Patienten liegt eine Einverständniserklärung vor.

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Westekemper, H., Meller, D., Darawsha, R. et al. Operative Therapie und Bestrahlung konjunktivaler Melanome. Ophthalmologe 112, 899–906 (2015). https://doi.org/10.1007/s00347-015-0147-y

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