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Kidney transplantation in prostate cancer patients after local therapy with curative intent: a systematic review

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Abstract

Purpose

It is still unclear whether kidney transplantation can be safely performed in patients with prostate cancer after local therapy with curative intent.

Methods

The protocol was registered in PROSPERO. We systematically searched Google, MEDLINE, the Cochrane Library, and the ICTRP for studies, official standards, clinical practice guidelines and organ transplant laws. Two review authors independently examined the full-text reports and identified relevant studies and one review author extracted the data. We assessed the overall certainty of the evidence for each outcome according to the GRADE approach.

Results

We identified 1346 references through electronic database searching and finally included 6 references for official standards, clinical practice guidelines, and organ transplant laws, and 6 references for retrospective studies with very low certainty of evidence. We identified no prospective or ongoing studies and reported all results narratively.

Conclusion

We recommend that decisions on kidney transplantation in patients with prostate cancer after local therapy with curative intent should be made on a case-by-case basis. It is indispensable to consult with health care professionals or specialists at transplant centers to obtain individualized information regarding the waiting time requirements for renal transplantation in prostate cancer patients after local therapy with curative intent. No recommendation can be made regarding the waiting times after prostate cancer therapy with curative intent.

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Data availability

The protocol was registered in the ‘International prospective register of systematic reviews’ (http://www.crd.york.ac.uk/PROSPERO; CRD42023448319). The data were stored and organized using EndNote 20 Version (The EndNote Team, Philadelphia, PA, Clarivate Analytics).

Abbreviations

PSA:

Prostate-specific antigen

ISUP:

International Society of Urological Pathology

WHO:

World Health Organization

ICTRP:

International Clinical Trials Registry Platform

KDIGO:

The Kidney Disease: Improving Global Outcome

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Funding

The authors have received no external funding.

Author information

Author notes

  1. F. Kunath and H. Apel have contributed equally to this work.

Authors and Affiliations

  1. Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany

    C. Rumpff

  2. Department of Urology and Pediatric Urology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstraße 12, 91054, Erlangen, Germany

    V. Lieb, B. Wullich & H. Apel

  3. Transplant Centre Erlangen-Nürnberg, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

    V. Lieb, B. Wullich, M. Schiffer & H. Apel

  4. Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

    M. Schiffer

  5. Klinik für Urologie und Kinderurologie, Klinikum Bayreuth GmbH, Bayreuth, Germany

    F. Kunath

  6. Medizinische Fakultät am Medizincampus Oberfranken, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Deutschland

    F. Kunath

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Contributions

C Rumpff—first reviewer—contributed to development of hypotheses, protocol drafting and registration, collation of previous findings, search strategy development, systematic research using different databases, title and abstract screening, acquiring trial reports, full-text screening, data extraction, quality of evidence assessment, data analysis, data interpretation, classification in scientific context, and review drafting, GRADE assessment, manuscript writing/editing and submission. F Kunath—second reviewer—contributed to protocol drafting, search strategy development, full-text screening, quality of evidence assessment, data interpretation, data analysis, review drafting, and critical review of manuscript. GRADE assessment. H Apel—third reviewer—contributed to data analysis, data interpretation, and critical review of manuscript, is an expert in the field, GRADE assessment. M Schiffer, B Wullich helped with data analysis, review drafting, and critical review of manuscript, and they are experts in the field, GRADE assessment. The study is exempt from ethical committee approval because this systematic review did not involve human subjects or identifiable human material and data. All of the authors have read and approved the manuscript, and it has not been submitted elsewhere.

Corresponding author

Correspondence to H. Apel.

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The present work was performed in fulfillment of the requirements for obtaining the degree “Dr. med.”.

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Rumpff, C., Lieb, V., Wullich, B. et al. Kidney transplantation in prostate cancer patients after local therapy with curative intent: a systematic review. World J Urol 42, 127 (2024). https://doi.org/10.1007/s00345-024-04817-5

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