References
Watson PA, Arora VK, Sawyers CL (2015) Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer. Nat Rev Cancer 15:701–711. doi:10.1038/nrc4016
Hegemann M, Stenzl A, Bedke J et al (2016) Liquid biopsy: ready to guide therapy in advanced prostate cancer? BJU Int 118:855–863. doi:10.1111/bju.13586
Antonarakis ES, Lu C, Wang H et al (2014) AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer. N Engl J Med 371:1028–1038. doi:10.1056/NEJMoa1315815
Antonarakis ES, Lu C, Luber B et al (2015) Androgen receptor splice variant 7 and efficacy of taxane chemotherapy in patients with metastatic castration-resistant prostate cancer. JAMA Oncol. doi:10.1001/jamaoncol.2015.1341
Steinestel J, Luedeke M, Arndt A, et al (2015) Detecting predictive androgen receptor modifications in circulating prostate cancer cells. Oncotarget. doi:10.18632/oncotarget.3925
Onstenk W, Onstenk W, Sieuwerts AM et al (2015) Efficacy of cabazitaxel in castration-resistant prostate cancer is independent of the presence of AR-V7 in circulating tumor cells. Eur Urol. doi:10.1016/j.eururo.2015.07.007
Scher HI, Lu D, Schreiber NA et al (2016) Association of AR-V7 on circulating tumor cells as a treatment-specific biomarker with outcomes and survival in castration-resistant prostate cancer. JAMA. Oncol. doi:10.1001/jamaoncol.2016.1828
Liu X, Ledet E, Li D et al (2016) A whole blood assay for AR-V7 and AR(v567es) in patients with prostate cancer. J Urol 196:1758–1763. doi:10.1016/j.juro.2016.06.095
Qu F, Xie W, Nakabayashi M et al (2016) Association of AR-V7 and prostate specific antigen RNA levels in blood with efficacy of abiraterone acetate and enzalutamide treatment in men with prostate cancer. Clin Cancer Res. doi:10.1158/1078-0432.CCR-16-1070
Todenhöfer T, Azad A, Stewart C et al (2016) AR-V7 transcripts in whole blood RNA of patients with metastatic castration resistant prostate cancer correlate with response to Abiraterone acetate. J Urol 197:135–142. doi:10.1016/j.juro.2016.06.094
Takeuchi T, Okuno Y, Hattori-Kato M et al (2016) Detection of AR-V7 mRNA in whole blood may not predict the effectiveness of novel endocrine drugs for castration-resistant prostate cancer. Res Rep Urol 8:21–25. doi:10.2147/RRU.S98877
Pantel K, Alix-Panabieres C (2015) Functional studies on viable circulating tumor cells. Clin Chem. doi:10.1373/clinchem.2015.242537
de Wit S, van Dalum G, Lenferink ATM, et al (2015) The detection of EpCAM(+) and EpCAM(−) circulating tumor cells. Sci Rep 5:12270. doi:10.1038/srep12270
Del Re M, Biasco E, Crucitta S et al (2016) The detection of androgen receptor splice variant 7 in plasma-derived exosomal RNA strongly predicts resistance to hormonal therapy in metastatic prostate cancer patients. Eur Urol. doi:10.1016/j.eururo.2016.08.012
Fleige S, Walf V, Huch S et al (2006) Comparison of relative mRNA quantification models and the impact of RNA integrity in quantitative real-time RT-PCR. Biotechnol Lett 28:1601–1613. doi:10.1007/s10529-006-9127-2
Kim SH, Park WS, Lee SJ, et al (2015) The quantified level of circulating prostate stem cell antigen mRNA relative to GAPDH level is a clinically significant indictor for predicting biochemical recurrence in prostate cancer patients after radical prostatectomy. Biomed Res Int 2015:292454. doi:10.1155/2015/292454
Ma Y, Luk A, Young FP et al (2016) Droplet digital PCR based androgen receptor variant 7 (AR-V7) detection from prostate cancer patient blood biopsies. Int J Mol Sci. doi:10.3390/ijms17081264
Qu Y, Dai B, Ye D, et al (2015) Constitutively active AR-V7 plays an essential role in the development and progression of castration-resistant prostate cancer. Sci Rep 5:7654. doi:10.1038/srep07654
Yu Z, Yu Z, Chen S et al (2014) Rapid induction of androgen receptor splice variants by androgen deprivation in prostate cancer. Clin Cancer Res 20:1590–1600. doi:10.1158/1078-0432.CCR-13-1863
Robinson D, Robinson D, Van Allen EM et al (2015) Integrative clinical genomics of advanced prostate cancer. Cell 161:1215–1228. doi:10.1016/j.cell.2015.05.001
Guedes LB, Morais CL, Almutairi F et al (2016) Analytic validation of RNA in situ hybridization (RISH) for AR and AR-V7 expression in human prostate cancer. Clin Cancer Res. doi:10.1158/1078-0432.CCR-16-0205
Antonarakis ES, Luo J (2016) Blood based detection of androgen receptor splice variants in. J Urol. doi:10.1016/j.juro.2016.09.001
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Bernemann, C., Steinestel, J., Boegemann, M. et al. Novel AR-V7 detection in whole blood samples in patients with prostate cancer: not as simple as it seems. World J Urol 35, 1625–1627 (2017). https://doi.org/10.1007/s00345-017-2024-6
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DOI: https://doi.org/10.1007/s00345-017-2024-6