Abstract
Objective
Epidemiological research of recent years has produced evidence for a role of lifestyle-associated risk factors in the etiology of renal cell carcinoma (RCC), the most common renal tumor. In this review, we give an overview of recent trends in incidence and mortality and summarize the current knowledge on risk factors of RCC.
Methods
Data on incidence and mortality in the literature were reviewed. Global incidence data were derived from the Globocan database. A literature review of epidemiological studies on risk factors of kidney cancer was performed, with special emphasis on recent studies with high level of evidence, i.e., meta-analyses and prospective cohort studies.
Results
The incidence of renal malignancies has increased over recent decades in the context of the more widespread use of diagnostic imaging. However, time trends and geographic variations in incidence and mortality may also relate to changes in the prevalence of risk factors. Cigarette smoking, excess body weight and uncontrolled blood pressure are the most important and modifiable risk factors for RCC with a high prevalence in the general population. Moreover, dietary habits associated with a Western lifestyle were proposed as potential risk factors, but no food or food group has consistently been related to RCC risk.
Conclusion
Based on the current evidence, reductions in the prevalence of cigarette smoking, overweight and hypertension are preventive strategies for RCC. More research is needed to establish the underlying mechanisms linking these risk factors and renal carcinogenesis.
References
Mathew A, Devesa SS, Fraumeni JF Jr, Chow WH (2002) Global increases in kidney cancer incidence, 1973–1992. Eur J Cancer Prev 11:171–178
Hollingsworth JM, Miller DC, Daignault S, Hollenbeck BK (2006) Rising incidence of small renal masses: a need to reassess treatment effect. J Natl Cancer Inst 98:1331–1334
Ferlay J, Bray F, Pisani P, Parkin DM (2004) GLOBOCAN 2002: cancer incidence, mortality, and prevalence worldwide. IARC Press, Lyon
Aron M, Nguyen MM, Stein RJ, Gill IS (2008) Impact of gender in renal cell carcinoma: an analysis of the SEER database. Eur Urol 54:133–140
Levi F, Ferlay J, Galeone C, Lucchini F, Negri E, Boyle P et al (2008) The changing pattern of kidney cancer incidence and mortality in Europe. BJU Int 101:949–958
Chow WH, Devesa SS (2008) Contemporary epidemiology of renal cell cancer. Cancer J 14:288–301
Levi F, Lucchini F, Negri E, La Vecchia C (2004) Declining mortality from kidney cancer in Europe. Ann Oncol 15:1130–1135
Hunt JD, van der Hel OL, McMillan GP, Boffetta P, Brennan P (2005) Renal cell carcinoma in relation to cigarette smoking: meta-analysis of 24 studies. Int J Cancer 114:101–108
Theis RP, Dolwick Grieb SM, Burr D, Siddiqui T, Asal NR (2008) Smoking, environmental tobacco smoke, and risk of renal cell cancer: a population-based case–control study. BMC Cancer 8:387
Hu J, Ugnat AM (2005) Active and passive smoking and risk of renal cell carcinoma in Canada. Eur J Cancer 41:770–778
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371:569–578
Adams KF, Leitzmann MF, Albanes D, Kipnis V, Moore SC, Schatzkin A et al (2008) Body size and renal cell cancer incidence in a large US cohort study. Am J Epidemiol 168:268–277
Luo J, Margolis KL, Adami HO, Lopez AM, Lessin L, Ye W (2007) Body size, weight cycling, and risk of renal cell carcinoma among postmenopausal women: the Women’s Health Initiative (United States). Am J Epidemiol 166:752–759
Pischon T, Lahmann PH, Boeing H, Tjonneland A, Halkjaer J, Overvad K et al (2006) Body size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer 118:728–738
Chow WH, Gridley G, Fraumeni JF Jr, Jarvholm B (2000) Obesity, hypertension, and the risk of kidney cancer in men. N Engl J Med 343:1305–1311
Flaherty KT, Fuchs CS, Colditz GA, Stampfer MJ, Speizer FE, Willett WC et al (2005) A prospective study of body mass index, hypertension, and smoking and the risk of renal cell carcinoma (United States). Cancer Causes Control 16:1099–1106
Fryzek JP, Poulsen AH, Johnsen SP, McLaughlin JK, Sorensen HT, Friis S (2005) A cohort study of antihypertensive treatments and risk of renal cell cancer. Br J Cancer 92:1302–1306
Vatten LJ, Trichopoulos D, Holmen J, Nilsen TI (2007) Blood pressure and renal cancer risk: the HUNT Study in Norway. Br J Cancer 97:112–114
Weikert S, Boeing H, Pischon T, Weikert C, Olsen A, Tjonneland A et al (2008) Blood pressure and risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition. Am J Epidemiol 167:438–446
Shapiro JA, Williams MA, Weiss NS, Stergachis A, LaCroix AZ, Barlow WE (1999) Hypertension, antihypertensive medication use, and risk of renal cell carcinoma. Am J Epidemiol 149:521–530
Denton MD, Magee CC, Ovuworie C, Mauiyyedi S, Pascual M, Colvin RB et al (2002) Prevalence of renal cell carcinoma in patients with ESRD pre-transplantation: a pathologic analysis. Kidney Int 61:2201–2209
Lindblad P, Chow WH, Chan J, Bergstrom A, Wolk A, Gridley G et al (1999) The role of diabetes mellitus in the aetiology of renal cell cancer. Diabetologia 42:107–112
Setiawan VW, Stram DO, Nomura AM, Kolonel LN, Henderson BE (2007) Risk factors for renal cell cancer: the multiethnic cohort. Am J Epidemiol 166:932–940
Siemiatycki J, Richardson L, Straif K, Latreille B, Lakhani R, Campbell S et al (2004) Listing occupational carcinogens. Environ Health Perspect 112:1447–1459
Lee JE, Mannisto S, Spiegelman D, Hunter DJ, Bernstein L, van den Brandt PA et al (2009) Intakes of fruit, vegetables, and carotenoids and renal cell cancer risk: a pooled analysis of 13 prospective studies. Cancer Epidemiol Biomarkers Prev 18:1730–1739
George SM, Park Y, Leitzmann MF, Freedman ND, Dowling EC, Reedy J et al (2009) Fruit and vegetable intake and risk of cancer: a prospective cohort study. Am J Clin Nutr 89:347–353
Faramawi MF, Johnson E, Fry MW, Sall M, Zhou Y (2007) Consumption of different types of meat and the risk of renal cancer: meta-analysis of case–control studies. Cancer Causes Control 18:125–133
Lee JE, Spiegelman D, Hunter DJ, Albanes D, Bernstein L, van den Brandt PA et al (2008) Fat, protein, and meat consumption and renal cell cancer risk: a pooled analysis of 13 prospective studies. J Natl Cancer Inst 100:1695–1706
Wolk A, Larsson SC, Johansson JE, Ekman P (2006) Long-term fatty fish consumption and renal cell carcinoma incidence in women. JAMA 296:1371–1376
Lee JE, Hunter DJ, Spiegelman D, Adami HO, Albanes D, Bernstein L et al (2007) Alcohol intake and renal cell cancer in a pooled analysis of 12 prospective studies. J Natl Cancer Inst 99:801–810
Allen NE, Roddam AW, Sieri S, Boeing H, Jakobsen MU, Overvad K et al (2009) A prospective analysis of the association between macronutrient intake and renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer 125:982–987
Hu J, La Vecchia C, Negri E, Desmeules M, Mery L (2009) Dietary vitamin C, E, and carotenoid intake and risk of renal cell carcinoma. Cancer Causes Control 20:1451–1458
Bosetti C, Scotti L, Maso LD, Talamini R, Montella M, Negri E et al (2007) Micronutrients and the risk of renal cell cancer: a case–control study from Italy. Int J Cancer 120:892–896
Karami S, Brennan P, Rosenberg PS, Navratilova M, Mates D, Zaridze D et al (2009) Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk. PLoS One 4:e7013
Gago-Dominguez M, Yuan JM, Castelao JE, Ross RK, Yu MC (2001) Family history and risk of renal cell carcinoma. Cancer Epidemiol Biomarkers Prev 10:1001–1004
Clague J, Lin J, Cassidy A, Matin S, Tannir NM, Tamboli P et al (2009) Family history and risk of renal cell carcinoma: results from a case–control study and systematic meta-analysis. Cancer Epidemiol Biomarkers Prev 18:801–807
Gudbjartsson T, Jonasdottir TJ, Thoroddsen A, Einarsson GV, Jonsdottir GM, Kristjansson K et al (2002) A population-based familial aggregation analysis indicates genetic contribution in a majority of renal cell carcinomas. Int J Cancer 100:476–479
Linehan WM, Vasselli J, Srinivasan R, Walther MM, Merino M, Choyke P et al (2004) Genetic basis of cancer of the kidney: disease-specific approaches to therapy. Clin Cancer Res 10:6282S–6289S
Benichou J, Chow WH, McLaughlin JK, Mandel JS, Fraumeni JF Jr (1998) Population attributable risk of renal cell cancer in Minnesota. Am J Epidemiol 148:424–430
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Weikert, S., Ljungberg, B. Contemporary epidemiology of renal cell carcinoma: perspectives of primary prevention. World J Urol 28, 247–252 (2010). https://doi.org/10.1007/s00345-010-0555-1
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DOI: https://doi.org/10.1007/s00345-010-0555-1