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A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice

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Abstract

We have studied the genetics of susceptibility to infection by Streptococcus pneumoniae in mice. Linkage analysis of the F2 generation from a cross between resistant BALB/cO1aHsd and susceptible CBA/CaO1aHsd strains allowed us to map a major locus controlling the development of bacteremia and survival after intranasal infection.

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Acknowledgements

We thank Martin Farrall and Jonathan Flint for discussions about linkage analysis, and Jackie King for technical support. This work was supported by the Medical Research Council and AstraZeneca UK Limited.

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Authors and Affiliations

  1. MRC UK Mouse Genome Centre & Mammalian Genetics Unit, Harwell, Oxon, OX11 0RD, UK

    Paul Denny, Elaine Hopes & Steve D. M. Brown

  2. Department of Microbiology and Immunology, University of Leicester, Leicester, UK

    Neill Gingles, Janet Alexander & Peter W. Andrew

  3. Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland, USA

    Karl W. Broman

  4. Research and Development Genetics, AstraZeneca, Alderley Park, Macclesfield, Cheshire, UK

    John Morten

  5. Cell Biology and Biochemistry, AstraZeneca R&D Mölndal, Pepparedsleden 1, 431 83 Mölndal, Sweden

    William McPheat

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  1. Paul Denny
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  2. Elaine Hopes
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  3. Neill Gingles
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  4. Karl W. Broman
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  7. Janet Alexander
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  8. Peter W. Andrew
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  9. Steve D. M. Brown
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Correspondence to Paul Denny.

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Denny, P., Hopes, E., Gingles, N. et al. A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice . Mamm Genome 14, 448–453 (2003). https://doi.org/10.1007/s00335-002-2261-9

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  • DOI: https://doi.org/10.1007/s00335-002-2261-9

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