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Rectal cancer with complete endoscopic response after neoadjuvant therapy: what is the meaning of a positive MRI?

  • Gastrointestinal
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Objectives

To determine the short-term outcomes of discordant tumor assessments between DWI-MRI and endoscopy in patients with treated rectal cancer when tumor-bed diffusion restriction is present (“+DWI”).

Methods

In this HIPPA-compliant, IRB-approved retrospective study, rectal MRI and endoscopic reports were reviewed for patients with locally advanced primary rectal adenocarcinoma (LARC) treated with chemoradiotherapy or total neoadjuvant therapy and imaged between January 2016 and December 2019. Eligible patients had a +DWI and endoscopy within 2 weeks of each other. True positive MRI were those with tumor on endoscopy and/or biopsy (TPa) or in whom endoscopy was negative for tumor, but subsequent 3-month follow-up endoscopy and DWI were both positive (TPb). The positive predictive value of DWI-MRI was calculated on a per-scan and per-patient basis. DWI-negative MRI exams were not explored in this study.

Results

In total, 397 patients with nonmetastatic primary LARC were analyzed. After exclusions, 90 patients had 98 follow-up rectal MRI studies with +DWI. Seventy-six patients underwent 80 MRI scans and had concordant findings at endoscopy (TPa). Seventeen patients underwent 18 MRI scans and had discordant findings at endoscopy (FP); among these, 4 scans in 4 patients were initially false positive (FP) but follow-up MRI remained +DWI and the endoscopy turned concordantly positive (TPb). PPV was 0.86 per scan and per patient. In 4/18 (22%) scans and 4/17 (24%) patients with discordances, MRI detected tumor regrowth before endoscopy.

Conclusions

Although most +DWI exams discordant with endoscopy are false positive, 22% will reveal that DWI-MRI detects tumor recurrence before endoscopy.

Key Points

• Most often, in post-treatment assessment for rectal cancer when DWI-MRI shows restriction in the tumor bed and endoscopy shows no tumor, +DWI MRI will be proven false positive.

• Conversely, our study demonstrated that, allowing for sequential follow-up at a 3-month maximum interval, DWI-MRI may detect tumor presence in the treated tumor bed before endoscopy in 22% of discordant findings between DWI-MRI and endoscopy.

• Our results showed that a majority of DWI-MRI-positive scans in treated rectal cancer concur with the presence of tumor on endoscopy performed within 2 weeks.

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Abbreviations

+DWI:

Diffusion restriction is present at diffusion-weighted imaging with associated low signal on the ADC map

cCR:

Clinical complete response

cGy:

Centi-Gray

CR:

Complete response

CRT:

Chemoradiotherapy

DWI-MRI:

Diffusion-weighted magnetic resonance imaging

ESGAR:

European Society of Gastrointestinal and Abdominal Radiology

FOV:

Field of view

GE:

General Electric

HIPPA:

Health Insurance Portability and Protection Act

NEX:

Number of signal averages

OPRA:

Organ Preservation in Rectal Adenocarcinoma

SS:

Surveillance scans

T2W:

T2-Weighted imaging

TE:

Time to echo

TME:

Total mesorectal excision

TNT:

Total neoadjuvant treatment

TPa:

True positive, conventional definition

TPb:

True positive after initial false positive and allowing for 3 months

TR:

Time to recovery

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Funding

The authors state that this work has not received any funding.

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Authors and Affiliations

  1. Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA

    Marc J. Gollub, Jeeban P. Das, David D. B. Bates, J. Louis Fuqua III, Jennifer S. Golia Pernicka, Sidra Javed-Tayyab, Viktoriya Paroder & Iva Petkovska

  2. Division of Colorectal, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA

    Julio Garcia-Aguilar

Authors
  1. Marc J. Gollub
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Correspondence to Marc J. Gollub.

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The scientific guarantor of this publication is Marc J Gollub.

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The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

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Gollub, M.J., Das, J.P., Bates, D.D.B. et al. Rectal cancer with complete endoscopic response after neoadjuvant therapy: what is the meaning of a positive MRI?. Eur Radiol 31, 4731–4738 (2021). https://doi.org/10.1007/s00330-020-07657-0

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